From: A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell lines
Standard Bcl-2 expression and pBcl-2(s70) phosphorylation | Down-regulated Bcl-2; standard pBcl-2(s70) phosphorylation | Down-regulated Bcl-2 expression and pBcl-2(s70) phosphorylation | Standard Bcl-2 expression; down-regulated pBcl-2(s70) phosphorylation | |
---|---|---|---|---|
MCF-7 cells | ||||
Vehicle-treated cells | 99.2% | 0.6% | 0.1% | 0.0% |
EMBS-treated cells | 63.06%* | 0.0% | 14.2% | 22.69%* |
Actinomycin D-treated cells | 36.53%* | 54.38%* | 9.0% | 0.0% |
MDA-MB-231 cells | ||||
Vehicle-treated cells | 99.3% | 0.0% | 0.3% | 0.3% |
EMBS-treated cells | 61.75%* | 9.5% | 17.4% | 11.4% |
Actinomycin D-treated cells | 27.78%* | 65.13%* | 7.1% | 0.0% |
MCF-12A cells | ||||
Vehicle-treated cells | 99.1% | 0.1% | 0.7% | 0.0% |
EMBS-treated cells | 70.14%* | 0.6% | 10.9% | 18.3% |
Actinomycin D-treated cells | 35.07%* | 50.18%* | 35.07%* | 0.4% |