Skip to main content

Advertisement

Table 3 Data regarding Bcl-2 protein expression and pBcl-2(s70) phosphorylation

From: A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell lines

  Standard Bcl-2 expression and pBcl-2(s70) phosphorylation Down-regulated Bcl-2; standard pBcl-2(s70) phosphorylation Down-regulated Bcl-2 expression and pBcl-2(s70) phosphorylation Standard Bcl-2 expression; down-regulated pBcl-2(s70) phosphorylation
MCF-7 cells
Vehicle-treated cells 99.2% 0.6% 0.1% 0.0%
EMBS-treated cells 63.06%* 0.0% 14.2% 22.69%*
Actinomycin D-treated cells 36.53%* 54.38%* 9.0% 0.0%
MDA-MB-231 cells
Vehicle-treated cells 99.3% 0.0% 0.3% 0.3%
EMBS-treated cells 61.75%* 9.5% 17.4% 11.4%
Actinomycin D-treated cells 27.78%* 65.13%* 7.1% 0.0%
MCF-12A cells
Vehicle-treated cells 99.1% 0.1% 0.7% 0.0%
EMBS-treated cells 70.14%* 0.6% 10.9% 18.3%
Actinomycin D-treated cells 35.07%* 50.18%* 35.07%* 0.4%
  1. *Statistical significance at P <0.05 compared to vehicle-treated cells in a paired student T-test.