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Table 3 Data regarding Bcl-2 protein expression and pBcl-2(s70) phosphorylation

From: A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell lines

 

Standard Bcl-2 expression and pBcl-2(s70) phosphorylation

Down-regulated Bcl-2; standard pBcl-2(s70) phosphorylation

Down-regulated Bcl-2 expression and pBcl-2(s70) phosphorylation

Standard Bcl-2 expression; down-regulated pBcl-2(s70) phosphorylation

MCF-7 cells

Vehicle-treated cells

99.2%

0.6%

0.1%

0.0%

EMBS-treated cells

63.06%*

0.0%

14.2%

22.69%*

Actinomycin D-treated cells

36.53%*

54.38%*

9.0%

0.0%

MDA-MB-231 cells

Vehicle-treated cells

99.3%

0.0%

0.3%

0.3%

EMBS-treated cells

61.75%*

9.5%

17.4%

11.4%

Actinomycin D-treated cells

27.78%*

65.13%*

7.1%

0.0%

MCF-12A cells

Vehicle-treated cells

99.1%

0.1%

0.7%

0.0%

EMBS-treated cells

70.14%*

0.6%

10.9%

18.3%

Actinomycin D-treated cells

35.07%*

50.18%*

35.07%*

0.4%

  1. *Statistical significance at P <0.05 compared to vehicle-treated cells in a paired student T-test.