Figure 8
From: A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell lines
Caspase 8 activation by EMBS. Caspase 8 activity ratios of EMBS- and actinomycin D-treated cells compared to vehicle-treated cells. EMBS-treated MDA-MB-231 cells possessed the highest caspase 8 activity, followed by MCF-7 and MCF-12A. Actinomycin D-treated cells were used as a positive control for apoptosis and caspase activation and displayed significant elevated caspase 8 activity above 2.5 fold when compared to vehicle-treated cells.