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Figure 10 | Cell & Bioscience

Figure 10

From: A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell lines

Figure 10

Effects of EMBS on Bcl-2 expression and pBcl-2(s70) phosphorylation. Flow cytometry investigation of Bcl-2 expression (FL1 Log) and pBcl-2(s70) phosphorylation (FL3 Log) of vehicle-treated MCF-7 (A), MDA-MB-231 (B) and MCF-12A cells (C). Treated cells were exposed to 0.4 μM for 24 h and demonstrated a downregulated protein expression of Bcl-2 and pBcle-2(s70) phosphorylation status in MCF-7 (D), MDA-MB-231 (E) and MCF-12A cells (F). Actinomycin D-treated cells were used as a positive control for apoptosis and showed a decrease in Bcl-2 protein expression and Bcl-2(s70) phosphorylation status in MCF-7 (G), MDA-MB-231 (H) and MCF-12A cells (I).

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