Table 1 Up-regulated proteins were identified by a SILAC-based proteomic approach

Commonly up-regulated proteins

1

IPI00022418

FN1

Isoform 1 of Fibronectin

6.525

0.0000

1.7

1.9

17.7

4.8

2

IPI00011229

CTSD

Cathepsin D

3.200

0.0000

2.9

3.2

3.4

3.3

3

IPI00026314

GSN

Isoform 1 of Gelsolin

2.375

0.0000

3

2.6

2

1.9

4

IPI00020632

ASS1

Argininosuccinate synthase

2.175

0.0007

2.3

2.1

2.4

1.9

5

IPI00024915

PRDX5

Isoform Mitochondrial of Peroxiredoxin-5, mitochondrial

2.025

0.0606

2.9

1.8

1.5

1.9

6

IPI00019157

CSPG4

Chondroitin sulfate proteoglycan 4

1.900

0.3173

1.4

1

2

3.2

7

IPI00218474

ENO3

Isoform 1 of Beta-enolase

1.900

0.0145

1

1

4.6

1

8

IPI00005707

MRC2

C-type mannose receptor 2

1.850

0.0074

1.3

1.2

2.5

2.4

9

IPI00940829

NEDD4

Isoform 4 of E3 ubiquitin-protein ligase NEDD4

1.850

0.0004

1.3

1.3

2.4

2.4

10

IPI00021048

MYOF

Isoform 1 of Myoferlin

1.800

0.0000

1.8

1.7

2.4

1.3

11

IPI00021812

AHNAK

Neuroblast differentiation-associated protein AHNAK

1.800

0.0047

1.8

2.2

1.6

1.6

12

IPI00020557

LRP1

Prolow-density lipoprotein receptor-related protein 1

1.800

0.0000

1.4

1.4

1.8

2.6

13

IPI00021766

RTN4

Isoform 1 of Reticulon-4

1.725

0.0019

1.6

1.5

1.7

2.1

14

IPI00006663

ALDH2

Aldehyde dehydrogenase, mitochondrial

1.625

0.0262

2.1

1.8

1.4

1.2

Single (10 Gy)

1

IPI00011229

CTSD

Cathepsin D

3.05

2.9

3.2

2

IPI00026314

GSN

Isoform 1 of Gelsolin

2.8

3

2.6

3

IPI00024915

PRDX5

Isoform Mitochondrial of Peroxiredoxin-5, mitochondrial

2.35

2.9

1.8

4

IPI00020632

ASS1

Argininosuccinate synthase

2.2

2.3

2.1

5

IPI00021812

AHNAK

Neuroblast differentiation-associated protein AHNAK

2

1.8

2.2

6

IPI00006663

ALDH2

Aldehyde dehydrogenase, mitochondrial

1.95

2.1

1.8

7

IPI00022418

FN1

Isoform 1 of Fibronectin

1.8

1.7

1.9

8

IPI00021048

MYOF

Isoform 1 of Myoferlin

1.75

1.8

1.7

9

IPI00021766

RTN4

Isoform 1 of Reticulon-4

1.55

1.6

1.5

10

IPI00216694

PLS3

Plastin-3

1.55

1.6

1.5

11

IPI00382844

ACO2

Aconitase (Fragment)

1.55

1.5

1.6

12

IPI00013860

HIBADH

3-hydroxyisobutyrate dehydrogenase, mitochondrial

1.55

1.5

1.6

13

IPI00018350

MCM5

DNA replication licensing factor MCM5

1.55

1.6

1.5

14

IPI00098902

OGDH

2-oxoglutarate dehydrogenase, mitochondrial

1.5

1.5

1.5

15

IPI00784156

AP2B1

Isoform 1 of AP-2 complex subunit beta

1.5

1.5

1.5

16

IPI00456969

DYNC1H1

Cytoplasmic dynein 1 heavy chain 1

1.5

1.5

1.5

Fraction (2 Gy × 5)

1

IPI00022418

FN1

Isoform 1 of Fibronectin

11.25

17.7

4.8

2

IPI00011229

CTSD

Cathepsin D

3.35

3.4

3.3

3

IPI00218474

ENO3

Isoform 1 of Beta-enolase

2.8

4.6

1

4

IPI00019157

CSPG4

Chondroitin sulfate proteoglycan 4

2.6

2

3.2

5

IPI00005707

MRC2

C-type mannose receptor 2

2.45

2.5

2.4

6

IPI00940829

NEDD4

Isoform 4 of E3 ubiquitin-protein ligase NEDD4

2.4

2.4

2.4

7

IPI00020557

LRP1

Prolow-density lipoprotein receptor-related protein 1

2.2

1.8

2.6

8

IPI00216457

HIST2H2AA3

Histone H2A type 2-A

2.2

2.3

2.1

9

IPI00020632

ASS1

Argininosuccinate synthase

2.15

2.4

1.9

10

IPI00026314

GSN

Isoform 1 of Gelsolin

1.95

2

1.9

11

IPI00018398

PSMC3

26S protease regulatory subunit 6A

1.95

2.8

1.1

12

IPI00021766

RTN4

Isoform 1 of Reticulon-4

1.9

1.7

2.1

13

IPI00021048

MYOF

Isoform 1 of Myoferlin

1.85

2.4

1.3

14

IPI00293464

DDB1

DNA damage-binding protein 1

1.75

1.4

2.1

15

IPI00815770

SNX3

Isoform 1 of Sorting nexin-3

1.75

2.3

1.2

16

IPI00024915

PRDX5

Isoform Mitochondrial of Peroxiredoxin-5, mitochondrial

1.7

1.5

1.9

17

IPI00007682

ATP6V1A

V-type proton ATPase catalytic subunit A

1.7

1.7

1.7

18

IPI00021812

AHNAK

Neuroblast differentiation-associated protein AHNAK

1.6

1.6

1.6

19

IPI00010418

MYO1C

Isoform 2 of Myosin-Ic

1.6

1.8

1.4

20

IPI00000005

NRAS

GTPase NRas

1.6

1.6

1.6

21

IPI00006482

ATP1A1

Isoform Long of Sodium/potassium-transporting ATPase subunit alpha-1

1.6

1.4

1.8

22

IPI00023006

ACTC1

Actin, alpha cardiac muscle 1

1.6

2.1

1.1

23

IPI00221035

BTF3

Isoform 1 of Transcription factor BTF3

1.6

1.6

1.6

24

IPI00007402

IPO7

Importin-7

1.55

2.2

0.9

25

IPI00246058

PDCD6IP

Programmed cell death 6-interacting protein

1.55

1.7

1.4

26

IPI00026689

CDK1

Putative uncharacterized protein DKFZp686L20222

1.5

1.5

1.5

27

IPI00001960

CLIC4

Chloride intracellular channel protein 4

1.5

1.4

1.6