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Figure 3 | Cell & Bioscience

Figure 3

From: High-resolution chromosomal microarray analysis of early-stage human embryonic stem cells reveals an association between X chromosome instability and skewed X inactivation

Figure 3

Different XCI patterns in heterozygous hESC lines. (A) shows random XCI in hES-25, hES-26 and hES-35 where two active and two inactive alleles of the HUMARA gene are detected. The peak area ratios between the two active or inactive alleles are 50:50, 64:36 and 60:40 respectively. (B) shows skewed XCI of hES-20, hES-27 and hES-39 where only one active allele and another different inactive allele of the HUMARA gene are detected. (C) shows normal female blood DNA as a control for random XCI (two active and two inactive alleles, 183 and 200 bp, respectively), and (D) shows normal male blood DNA with only a 190 bp active allele and no inactive allele detected. X-axis indicates the size (bp) of DNA product.

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