Mice genetically deficient in IL-25 are protected from acute dextran sulfate sodium (DSS)-induced colitis. Mice were given 3.2% DSS in drinking water for 7 days and euthanized at day 8. (A) Changes in body weight during the course of experiment, expressed as the percentage of initial body weight at day 0; (B) Clinical disease activity based on stool consistency (0–3), presence of blood in stool (0–2), and general appearance (0–2); (C) Colon length at euthanasia; (D) Representative H&E-stained colon sections (100X); (E) Histological activity index from a total score of epithelial damage (0–4) and inflammatory cell infiltration (0–4). Data are mean ± SEM and are representatives of three independent experiments with five mice per group. *P < 0.05 versus respective WT-DSS.