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Table 1 Average percentage of cells in interphase, various stages of mitosis and cells displaying apoptotic morphology

From: Induction of the intrinsic apoptotic pathway via a new antimitotic agent in an esophageal carcinoma cell line

  Interphase Prophase Metaphase Anaphase Telophase Apoptosis Abnormal
Medium 96.1% 0.6% 1.5% 0.4% 0.6% 0.5% 0.4%
DMSO 97.5% 0.2% 1.3% 0.2% 0.6% 0.2% 0.4%
Actinomycin D 60.2% 0.3% 2.5% 0% 0.5% 33.8% 2.3%
ESE-16 27.3% 0.7% 46.0%* 0.2% 0.4% 21.4%* 4.2%
  1. Mitotic indices revealed a significant increase, with a P-value of 0.0003*, in the percentage of cells in metaphase in the ESE-16-treated samples (46.0%) when compared to the vehicle control (1.3%). ESE-16-treated cells also showed a significant increase (P-value of 0.0006*) in the percentage of cells undergoing apoptosis (21.4%) when compared to the vehicle control (0.2%).