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Table 2 Association of the genetic variants of glutamate receptor family genes in Taiwanese KD children according to the presence or absence of CAA

From: Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms

SNP Chromosome Cytoband Physical position Nearest genes KD CAA- KD CAA+
   No. (%) No. (%) p value Odds ratio (95% CI)
rs466013 21 q21.3 29826390 GRIK1 TT + TC 83 (44.9) 48 (63.2) 0.007 2.11 ( 1.22-3.65 )
  CC 102 (55.1) 28 (36.8)   1
rs425507 21 q21.3 29827658 GRIK1 G + GA 82 (44.1) 48 (63.2) 0.01 2.17 ( 1.26-3.76 )
  AA 104 (55.9) 28 (36.8)   1
rs388700 21 q21.3 29830158 GRIK1 TT + TA 81 (44.1) 48 (63.2) 0.004 2.20 ( 1.27-3.81 )
  AA 104 (55.9) 28 (36.8)   1
rs402280 21 q21.3 29835401 GRIK1 TT + TA 74 (39.8) 42 (55.2) 0.022 1.87 ( 1.09-3.21 )
  AA 112 (60.2) 34 (44.8)   1
rs17816480 6 q16.3 101522140 GRIK2 TT + TC 30 (16.1) 18 (23.7) 0.151 1.61 (0.84-3.11)
  CC 156 (83.9) 58 (76.3)   1
rs2786239 6 q16.3 101637565 GRIK2 GG + GA 29 (15.6) 16 (21.1) 0.288 1.44 (0.73-2.85)
  AA 157 (84.4) 60 (78.9)   1
rs4840194 6 q16.3 101768497 GRIK2 CC + CT 64 (34.4)) 24 (31.6) 0.660 0.88 (0.50-1.56)
  TT 122 (65.6) 52 (68.4)   1
rs1310715 6 q16.3 101961427 GRIK2 TT + TC 91 (49.2) 42 (55.3) 0.373 1.28 (0.75-2.18)
  CC 94 (50.8) 34 (44.7)   1
rs527631 1 p34.3 36844396 GRIK3 AA + AG 32 (17.6) 13 (17.8) 0.966 1.02 (0.50-2.07)
  GG 150 (82.4) 60 (82.2)   1
rs476894 1 p34.3 36868682 GRIK3 GG + GA 45 (24.2) 18 (23.7) 0.930 0.97 (0.52-1.82)
  AA 141 (75.8) 58 (76.3)   1
rs541671 1 p34.3 36905238 GRIK3 TT + TA 47 (26.1) 18 (25.3) 0.902 0.96 (0.51-1.80)
  AA 133 (73.9) 53 (74.7)   1
rs35317705 1 p34.3 36972969 GRIK3 CC + CT 22 (11.8) 11 (14.5) 0.558 1.26 (0.58-2.75)
  TT 164 (88.2) 65 (85.5)   1
rs11218005 11 q23.3 120782227 GRIK4 AA + AC 27 (14.5) 8 (10.5) 0.389 0.69 (0.30-1.60)
  CC 159 (85.5) 68 (89.5)   1
rs3901285 11 q23.3 120862726 GRIK4 TT + TC 113 (60.7) 45 (59.2) 0.817 0.94 (0.54-1.62)
  CC 73 (39.3) 31 (40.8)   1
rs4936566 11 q23.3 120944529 GRIK4 AA + AG 104 (55.9) 41 (54.0) 0.771 0.92 (0.54-1.58)
  GG 82 (44.1) 35 (46.0)   1
rs443239 19 q13.2 42001892 GRIK5 CC + CG 45 (24.2) 19 (25.0) 0.890 1.04 (0.56-1.94)
  GG 141 (75.8) 57 (75.0)   1
rs1493395 5 q33.2 153532297 GRIA1 AA + AG 88 (47.3) 37 (48.7) 0.840 1.06 (0.62-1.80)
  GG 98 (52.7) 39 (51.3)   1
rs12153489 5 q33.2 153568777 GRIA1 TT + CT 40 (21.5) 19 (25.0) 0.539 1.22 (0.65-2.28)
  CC 146 (78.5) 57 (75.0)   1
rs4424038 5 q33.2 153740704 GRIA1 TT + CT 23 (12.4) 10 (13.2) 0.861 1.07 (0.48-2.38)
  CC 163 (87.6) 66 (86.8)   1
rs17035909 4 q32.1 157247565 GRIA2 AA + AT 66 (35.7) 21 (27.6) 0.210 0.69 (0.38-1.24)
  TT 119 (64.3) 55 (72.4)   1
rs17035959 4 q32.1 157302204 GRIA2 CC + AC 72 (38.7) 25 (32.9) 0.376 0.78 (0.44-1.36)
  AA 114 (61.3) 51 (67.1)   1
rs7695870 4 q32.1 157342624 GRIA2 TT + CT 50 (26.9) 26 (34.2) 0.236 1.41 (0.80-2.51)
  CC 136 (73.1) 50 (65.8)   1
rs6855973 4 q32.1 157365463 GRIA2 TT + AT 60 (33.2) 18 (24.0) 0.148 0.64 (0.34-1.18)
  AA 121 (66.8) 57 (76.0)   1
rs10895875 11 q22.3 105785485 GRIA4 AA + AT 130 (69.9) 51 (67.1) 0.673 1.16 (0.58-2.30)
  TT 56 (30.1) 25 (32.9)   1
rs4754136 11 q22.3 105846312 GRIA4 TT + CT 26(14.0) 5 (6.6) 0.092 0.43 (0.16-1.17)
  CC 160 (86.0) 71 (93.4)   1
rs17104835 11 q22.3 105971356 GRIA4 CC + CT 66 (35.7) 38 (50) 0.032 1.80 ( 1.05-3.10 )
  TT 119 (64.3) 38 (50)   1
rs7750018 6 q24.3 146206595 GRM1 CC + CT 43 (23.1) 19 (25.0) 0.745 1.11 (0.60-2.06)
  TT 143 (76.9) 57 (75.0)   1
rs362851 6 q24.3 146389448 GRM1 CC + CG 117 (62.9) 52 (68.4) 0.397 1.28 (0.72-2.25)
  GG 69 (37.1) 24 (31.6)   1
rs2300631 6 q24.3 146428918 GRM1 AA + AG 135 (72.7) 57 (75.0) 0.688 1.13 (0.62-2.09)
  GG 51 (27.4) 19 (25.0)   1
rs12023603 1 p21.2 51466999 GRM2 GG + AG 50 (26.9) 22 (28.9) 0.734 1.11 (0.61-2.00)
  AA 136 (73.1) 54 (71.1)   1
rs1983842 1 p21.2 51535259 GRM2 GG + AG 56 (30.1)) 23 (30.2) 0.980 1.01 (0.56-1.80)
  AA 130 (69.9) 53 (69.8)   1
rs802441 7 q21.11 86657787 GRM3 TT + CT 51 (27.4) 23 (30.2) 0.643 1.15 (0.64-2.06)
  CC 135 (72.6) 53 (69.8)   1
rs802466 7 q21.11 86698122 GRM3 CC + CT 35 (18.8) 9 (11.8) 0.171 0.58 (0.26-1.27)
  TT 151 (81.2) 67 (88.2)   1
rs12704286 7 q21.11 86745625 GRM3 AA + AG 60 (33.3) 27 (38.6) 0.435 1.26 (0.71-2.23)
  GG 120 (66.7) 43 (61.4)   1
rs17697415 7 q21.11 86772500 GRM3 AA + AG 22 (11.8) 12 (15.8) 0.387 1.40 (0.65-2.99)
  GG 164 (88.2) 64 (84.2)   1
rs1873254 6 p21.31 34058712 GRM4 AA + AG 105 (57.4) 43 (57.3) 0.995 1.00 (0.58-1.72)
  GG 78 (42.6) 32 (42.7)   1
rs937039 6 p21.31 34075875 GRM4 GG + AG 44 (23.6) 17 (22.4) 0.823 0.93 (0.49-1.76)
  AA 142 (76.4) 59 (77.6)   1
rs1565361 6 p21.31 34089248 GRM4 CC + CT 84 (45.2) 33 (43.4) 0.797 0.93 (0.54-1.60)
  TT 102 (54.8) 43 (56.6)   1
rs4106126 11 q14.2 88647181 GRM5 TT + CT 43 (23.1) 18 (23.7) 0.922 1.03 (0.55-1.94)
  CC 143 (76.9) 58 (76.3)   1
rs1391878 11 q14.2 88713212 GRM5 CC + CT 39 (21.0) 19 (25.0) 0.476 1.26 (0.67-2.35)
  TT 147 (79.0) 57 (75.0)   1
rs12787863 11 q14.2 88810547 GRM5 AA + AG 77 (41.4) 33 (43.4) 0.763 1.09 (0.63-1.86)
  GG 109 (58.6) 43 (56.6)   1
rs7126679 11 q14.2 89020677 GRM5 AA + AG 109 (59.9) 48 (64.0) 0.539 1.19 (0.68-2.08)
  GG 73 (40.1) 27 (36.0)   1
rs2856354 5 q35.3 178978728 GRM6 GG + AG AA 81 (43.6) 37 (48.7) 0.448 1.23 (0.72-2.10)
  105 (56.4) 39 (51.3)   1
rs10464073 5 q35.3 178982284 GRM6 GG + AG 81 (43.6) 37 (48.7) 0.448 1.23 (0.72-2.10)
  AA 105 (56.4) 39 (51.3)   1
rs17078880 5 q35.3 178983436 GRM6 TT + CT 51 (27.7) 20 (26.7) 0.863 0.95 (0.52-1.74)
  CC 133 (72.3) 55 (73.3)   1
rs2645341 5 q35.3 178984314 GRM6 GG + AG 53 (28.5) 19 (25.0) 0.565 0.84 (0.45-1.54)
  AA 133 (71.5) 57 (75.0)   1
rs6764411 3 p26.1 7101864 GRM7 CC + AC 127 (68.3) 52 (68.4) 0.982 1.01 (0.57-1.79)
  AA 59 (31.7) 24 (31.6)   1
rs17697928 3 p26.1 7326084 GRM7 AA + AG 130 (69.9) 48 (63.2) 0.289 0.74 (0.42-1.29)
  GG 56 (30.1) 28 (36.8)   1
rs779741 3 p26.1 7541915 GRM7 CC + AC 124 (66.7) 48 (63.2) 0.587 0.86 (0.49-1.50)
  AA 62 (33.3) 28 (36.8)   1
rs1354405 3 p26.1 7690304 GRM7 GG + AG 103 (55.4) 38 (50.0) 0.428 0.81 (0.47-1.38)
  AA 83 (44.6) 38 (50.0)   1
rs712723 7 q31.33 126439090 GRM8 CC + CT 115 (61.8) 59 (77.6) 0.014 2.14 ( 1.16-3.6 )
  1
rs17627206 7 q31.33 126793483 GRM8 TT AA + AG 71 (38.2) 20 (10.7) 17 (22.4) 8 (10.5) 0.957 0.98 (0.41-2.32)
  GG 166 (89.3) 68 (89.5)   1
rs11563505 7 q31.33 127059729 GRM8 TT + CT 46 (24.7) 19 (25.0) 0.964 1.01 (0.55-1.88)
  CC 140 (75.3) 57 (75.0)   1
  1. Physical position of individual SNPs was based on the NCBI Assembly database: GRCH38 version.
  2. GRIK, glutamate receptor, ionotropic, kainate; GRIA, glutamate receptor, ionotropic, AMPA; GRM, glutamate receptor, metabotropic, SNP, single nucleotide polymorphism; CI, confidence interval.
  3. p-values were obtained by chi-square test (2 x 2 table).
  4. Bold italic are significant at p value <0.05.