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Table 2 Association of the genetic variants of glutamate receptor family genes in Taiwanese KD children according to the presence or absence of CAA

From: Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms

SNP

Chromosome

Cytoband

Physical position

Nearest genes

KD CAA-

KD CAA+

  

No. (%)

No. (%)

p value

Odds ratio (95% CI)

rs466013

21

q21.3

29826390

GRIK1

TT + TC

83 (44.9)

48 (63.2)

0.007

2.11 ( 1.22-3.65 )

 

CC

102 (55.1)

28 (36.8)

 

1

rs425507

21

q21.3

29827658

GRIK1

G + GA

82 (44.1)

48 (63.2)

0.01

2.17 ( 1.26-3.76 )

 

AA

104 (55.9)

28 (36.8)

 

1

rs388700

21

q21.3

29830158

GRIK1

TT + TA

81 (44.1)

48 (63.2)

0.004

2.20 ( 1.27-3.81 )

 

AA

104 (55.9)

28 (36.8)

 

1

rs402280

21

q21.3

29835401

GRIK1

TT + TA

74 (39.8)

42 (55.2)

0.022

1.87 ( 1.09-3.21 )

 

AA

112 (60.2)

34 (44.8)

 

1

rs17816480

6

q16.3

101522140

GRIK2

TT + TC

30 (16.1)

18 (23.7)

0.151

1.61 (0.84-3.11)

 

CC

156 (83.9)

58 (76.3)

 

1

rs2786239

6

q16.3

101637565

GRIK2

GG + GA

29 (15.6)

16 (21.1)

0.288

1.44 (0.73-2.85)

 

AA

157 (84.4)

60 (78.9)

 

1

rs4840194

6

q16.3

101768497

GRIK2

CC + CT

64 (34.4))

24 (31.6)

0.660

0.88 (0.50-1.56)

 

TT

122 (65.6)

52 (68.4)

 

1

rs1310715

6

q16.3

101961427

GRIK2

TT + TC

91 (49.2)

42 (55.3)

0.373

1.28 (0.75-2.18)

 

CC

94 (50.8)

34 (44.7)

 

1

rs527631

1

p34.3

36844396

GRIK3

AA + AG

32 (17.6)

13 (17.8)

0.966

1.02 (0.50-2.07)

 

GG

150 (82.4)

60 (82.2)

 

1

rs476894

1

p34.3

36868682

GRIK3

GG + GA

45 (24.2)

18 (23.7)

0.930

0.97 (0.52-1.82)

 

AA

141 (75.8)

58 (76.3)

 

1

rs541671

1

p34.3

36905238

GRIK3

TT + TA

47 (26.1)

18 (25.3)

0.902

0.96 (0.51-1.80)

 

AA

133 (73.9)

53 (74.7)

 

1

rs35317705

1

p34.3

36972969

GRIK3

CC + CT

22 (11.8)

11 (14.5)

0.558

1.26 (0.58-2.75)

 

TT

164 (88.2)

65 (85.5)

 

1

rs11218005

11

q23.3

120782227

GRIK4

AA + AC

27 (14.5)

8 (10.5)

0.389

0.69 (0.30-1.60)

 

CC

159 (85.5)

68 (89.5)

 

1

rs3901285

11

q23.3

120862726

GRIK4

TT + TC

113 (60.7)

45 (59.2)

0.817

0.94 (0.54-1.62)

 

CC

73 (39.3)

31 (40.8)

 

1

rs4936566

11

q23.3

120944529

GRIK4

AA + AG

104 (55.9)

41 (54.0)

0.771

0.92 (0.54-1.58)

 

GG

82 (44.1)

35 (46.0)

 

1

rs443239

19

q13.2

42001892

GRIK5

CC + CG

45 (24.2)

19 (25.0)

0.890

1.04 (0.56-1.94)

 

GG

141 (75.8)

57 (75.0)

 

1

rs1493395

5

q33.2

153532297

GRIA1

AA + AG

88 (47.3)

37 (48.7)

0.840

1.06 (0.62-1.80)

 

GG

98 (52.7)

39 (51.3)

 

1

rs12153489

5

q33.2

153568777

GRIA1

TT + CT

40 (21.5)

19 (25.0)

0.539

1.22 (0.65-2.28)

 

CC

146 (78.5)

57 (75.0)

 

1

rs4424038

5

q33.2

153740704

GRIA1

TT + CT

23 (12.4)

10 (13.2)

0.861

1.07 (0.48-2.38)

 

CC

163 (87.6)

66 (86.8)

 

1

rs17035909

4

q32.1

157247565

GRIA2

AA + AT

66 (35.7)

21 (27.6)

0.210

0.69 (0.38-1.24)

 

TT

119 (64.3)

55 (72.4)

 

1

rs17035959

4

q32.1

157302204

GRIA2

CC + AC

72 (38.7)

25 (32.9)

0.376

0.78 (0.44-1.36)

 

AA

114 (61.3)

51 (67.1)

 

1

rs7695870

4

q32.1

157342624

GRIA2

TT + CT

50 (26.9)

26 (34.2)

0.236

1.41 (0.80-2.51)

 

CC

136 (73.1)

50 (65.8)

 

1

rs6855973

4

q32.1

157365463

GRIA2

TT + AT

60 (33.2)

18 (24.0)

0.148

0.64 (0.34-1.18)

 

AA

121 (66.8)

57 (76.0)

 

1

rs10895875

11

q22.3

105785485

GRIA4

AA + AT

130 (69.9)

51 (67.1)

0.673

1.16 (0.58-2.30)

 

TT

56 (30.1)

25 (32.9)

 

1

rs4754136

11

q22.3

105846312

GRIA4

TT + CT

26(14.0)

5 (6.6)

0.092

0.43 (0.16-1.17)

 

CC

160 (86.0)

71 (93.4)

 

1

rs17104835

11

q22.3

105971356

GRIA4

CC + CT

66 (35.7)

38 (50)

0.032

1.80 ( 1.05-3.10 )

 

TT

119 (64.3)

38 (50)

 

1

rs7750018

6

q24.3

146206595

GRM1

CC + CT

43 (23.1)

19 (25.0)

0.745

1.11 (0.60-2.06)

 

TT

143 (76.9)

57 (75.0)

 

1

rs362851

6

q24.3

146389448

GRM1

CC + CG

117 (62.9)

52 (68.4)

0.397

1.28 (0.72-2.25)

 

GG

69 (37.1)

24 (31.6)

 

1

rs2300631

6

q24.3

146428918

GRM1

AA + AG

135 (72.7)

57 (75.0)

0.688

1.13 (0.62-2.09)

 

GG

51 (27.4)

19 (25.0)

 

1

rs12023603

1

p21.2

51466999

GRM2

GG + AG

50 (26.9)

22 (28.9)

0.734

1.11 (0.61-2.00)

 

AA

136 (73.1)

54 (71.1)

 

1

rs1983842

1

p21.2

51535259

GRM2

GG + AG

56 (30.1))

23 (30.2)

0.980

1.01 (0.56-1.80)

 

AA

130 (69.9)

53 (69.8)

 

1

rs802441

7

q21.11

86657787

GRM3

TT + CT

51 (27.4)

23 (30.2)

0.643

1.15 (0.64-2.06)

 

CC

135 (72.6)

53 (69.8)

 

1

rs802466

7

q21.11

86698122

GRM3

CC + CT

35 (18.8)

9 (11.8)

0.171

0.58 (0.26-1.27)

 

TT

151 (81.2)

67 (88.2)

 

1

rs12704286

7

q21.11

86745625

GRM3

AA + AG

60 (33.3)

27 (38.6)

0.435

1.26 (0.71-2.23)

 

GG

120 (66.7)

43 (61.4)

 

1

rs17697415

7

q21.11

86772500

GRM3

AA + AG

22 (11.8)

12 (15.8)

0.387

1.40 (0.65-2.99)

 

GG

164 (88.2)

64 (84.2)

 

1

rs1873254

6

p21.31

34058712

GRM4

AA + AG

105 (57.4)

43 (57.3)

0.995

1.00 (0.58-1.72)

 

GG

78 (42.6)

32 (42.7)

 

1

rs937039

6

p21.31

34075875

GRM4

GG + AG

44 (23.6)

17 (22.4)

0.823

0.93 (0.49-1.76)

 

AA

142 (76.4)

59 (77.6)

 

1

rs1565361

6

p21.31

34089248

GRM4

CC + CT

84 (45.2)

33 (43.4)

0.797

0.93 (0.54-1.60)

 

TT

102 (54.8)

43 (56.6)

 

1

rs4106126

11

q14.2

88647181

GRM5

TT + CT

43 (23.1)

18 (23.7)

0.922

1.03 (0.55-1.94)

 

CC

143 (76.9)

58 (76.3)

 

1

rs1391878

11

q14.2

88713212

GRM5

CC + CT

39 (21.0)

19 (25.0)

0.476

1.26 (0.67-2.35)

 

TT

147 (79.0)

57 (75.0)

 

1

rs12787863

11

q14.2

88810547

GRM5

AA + AG

77 (41.4)

33 (43.4)

0.763

1.09 (0.63-1.86)

 

GG

109 (58.6)

43 (56.6)

 

1

rs7126679

11

q14.2

89020677

GRM5

AA + AG

109 (59.9)

48 (64.0)

0.539

1.19 (0.68-2.08)

 

GG

73 (40.1)

27 (36.0)

 

1

rs2856354

5

q35.3

178978728

GRM6

GG + AG AA

81 (43.6)

37 (48.7)

0.448

1.23 (0.72-2.10)

 

105 (56.4)

39 (51.3)

 

1

rs10464073

5

q35.3

178982284

GRM6

GG + AG

81 (43.6)

37 (48.7)

0.448

1.23 (0.72-2.10)

 

AA

105 (56.4)

39 (51.3)

 

1

rs17078880

5

q35.3

178983436

GRM6

TT + CT

51 (27.7)

20 (26.7)

0.863

0.95 (0.52-1.74)

 

CC

133 (72.3)

55 (73.3)

 

1

rs2645341

5

q35.3

178984314

GRM6

GG + AG

53 (28.5)

19 (25.0)

0.565

0.84 (0.45-1.54)

 

AA

133 (71.5)

57 (75.0)

 

1

rs6764411

3

p26.1

7101864

GRM7

CC + AC

127 (68.3)

52 (68.4)

0.982

1.01 (0.57-1.79)

 

AA

59 (31.7)

24 (31.6)

 

1

rs17697928

3

p26.1

7326084

GRM7

AA + AG

130 (69.9)

48 (63.2)

0.289

0.74 (0.42-1.29)

 

GG

56 (30.1)

28 (36.8)

 

1

rs779741

3

p26.1

7541915

GRM7

CC + AC

124 (66.7)

48 (63.2)

0.587

0.86 (0.49-1.50)

 

AA

62 (33.3)

28 (36.8)

 

1

rs1354405

3

p26.1

7690304

GRM7

GG + AG

103 (55.4)

38 (50.0)

0.428

0.81 (0.47-1.38)

 

AA

83 (44.6)

38 (50.0)

 

1

rs712723

7

q31.33

126439090

GRM8

CC + CT

115 (61.8)

59 (77.6)

0.014

2.14 ( 1.16-3.6 )

 

1

rs17627206

7

q31.33

126793483

GRM8

TT AA + AG

71 (38.2) 20 (10.7)

17 (22.4) 8 (10.5)

0.957

0.98 (0.41-2.32)

 

GG

166 (89.3)

68 (89.5)

 

1

rs11563505

7

q31.33

127059729

GRM8

TT + CT

46 (24.7)

19 (25.0)

0.964

1.01 (0.55-1.88)

 

CC

140 (75.3)

57 (75.0)

 

1

  1. Physical position of individual SNPs was based on the NCBI Assembly database: GRCH38 version.
  2. GRIK, glutamate receptor, ionotropic, kainate; GRIA, glutamate receptor, ionotropic, AMPA; GRM, glutamate receptor, metabotropic, SNP, single nucleotide polymorphism; CI, confidence interval.
  3. p-values were obtained by chi-square test (2 x 2 table).
  4. Bold italic are significant at p value <0.05.