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Table 1 Genotype distribution of glutamate receptor family gene SNPs in Taiwanese KD patients and controls

From: Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms

SNP

Chromosome

Cytoband

Physical position

Nearest genes

 

Controls

KD patients

 

No. (%)

No. (%)

p value

Odds ratio (95% CI)

rs466013

21

q21.3

29826390

GRIK1

TT + TC

507 (45.9)

131 (50.2)

0.205

1.19 (0.91-1.56)

 

CC

599 (54.1)

130 (49.8)

 

1

rs425507

21

q21.3

29827658

GRIK1

GG + GA

507(45.8)

130 (49.6)

0.265

1.17 (0.89-1.53)

 

AA

600 (54.2)

132 (50.4)

 

1

rs388700

21

q21.3

29830158

GRIK1

TT + TA

506 (45.7)

130 (49.6)

0.254

1.17 (0.89-1.53)

 

AA

601 (54.3)

132 (50.4)

 

1

rs402280

21

q21.3

29835401

GRIK1

TT + TA

424 (38.3)

116 (44.3)

0.075

1.28 (0.97-1.68)

 

AA

683 (61.7)

146 (55.7)

 

1

rs17816480

6

q16.3

101522140

GRIK2

TT + TC

201 (18.2)

48 (18.3)

0.951

1.01 (0.71-1.43)

 

CC

906 (81.8)

214 (81.7)

 

1

rs2786239

6

q16.3

101637565

GRIK2

GG + GA

186 (16.8)

45 (17.2)

0.885

1.03 (0.72-1.47)

 

AA

921 (83.2)

217 (82.8)

 

rs4840194

6

q16.3

101768497

GRIK2

CC + CT

357 (32.2)

88 (33.6)

0.677

1.06 (0.80-1.41)

 

TT

750 (67.8)

174 (66.4)

 

1

rs1310715

6

q16.3

101961427

GRIK2

TT + TC

597 (53)

133 (50.9)

0.468

0.91 (0.69-1.91)

 

CC

520 (47.0)

128 (49.1)

 

1

rs527631

1

p34.3

36844396

GRIK3

AA + AG

172 (15.5)

45 (17.6)

0.407

1.16 (0.81-1.67)

 

GG

935 (84.5)

210 (82.4)

 

1

rs476894

1

p34.3

36868682

GRIK3

GG + GA

234 (21.1)

63 (24.0)

0.305

1.18 (0.86-1.62)

 

AA

873 (78.9)

199 (76.0)

 

1

rs541671

1

p34.3

36905238

GRIK3

TT + TA

267 (24.1)

65 (25.9)

0.554

1.10 (0.80-1.51)

 

AA

840 (75.9)

186 (74.1)

 

1

rs35317705

1

p34.3

36972969

GRIK3

CC + CT

128 (11.6)

33 (12.6)

0.641

1.10 (0.73-1.66)

 

TT

979 (88.4)

229 (87.4)

 

1

rs11218005

11

q23.3

120782227

GRIK4

AA + AC

132 (11.9)

35 (13.4)

0.523

1.14 (0.76-1.70)

 

CC

975 (88.1)

227 (86.6)

 

1

rs3901285

11

q23.3

120862726

GRIK4

TT + TC

650 (58.7)

158 (60.3)

0.638

1.07 (0.81-1.41)

 

CC

457 (41.3)

104 (39.7)

 

1

rs4936566

11

q23.3

120944529

GRIK4

AA + AG

669 (60.4)

145 (55.3)

0.131

0.81 (0.62-1.06)

 

GG

438 (39.6)

117 (44.7)

 

1

rs443239

19

q13.2

42001892

GRIK5

CC + CG

289 (26.1)

64 (24.4)

0.576

0.91 (0.67-1.25)

 

GG

818 (73.9)

198 (75.6)

 

1

rs1493395

5

q33.2

153532297

GRIA1

AA + AG

565 (51.1)

125 (47.7)

0.326

0.87 (0.67-1.14)

 

GG

541 (48.9)

137 (52.3)

 

1

rs12153489

5

q33.2

153568777

GRIA1

CC + CT

1087 (98.2)

259 (98.9)

0.454

1.59 (0.47-5.39)

 

TT

20 (1.8)

3 (1.1)

 

1

rs4424038

5

q33.2

153740704

GRIA1

CC + CT

1102 (99.5)

262 (100.0)

0.276

ND

 

TT

5 (0.5)

0 (0.0)

 

1

rs17035909

4

q32.1

157247565

GRIA2

AA + AT

351 (31.7)

87 (33.3)

0.640

1.07 (0.80-1.43)

 

TT

756 (68.3)

175 (66.7)

 

1

rs17035959

4

q32.1

157302204

GRIA2

AA + AC

1075 (97.1)

255 (97.3)

0.848

1.08 (0.47-2.48)

 

CC

32 (2.9)

7 (2.7)

 

1

rs7695870

4

q32.1

157342624

GRIA2

CC + CT

1082 (97.7)

258 (98.5)

0.460

1.49 (0.51-4.32)

 

TT

25 (2.3)

4 (1.5)

 

1

rs6855973

4

q32.1

157365463

GRIA2

AA + AT

1085 (98)

258 (98.4)

0.623

1.31 (0.45-3.83)

 

TT

22 (2.0)

4 (1.6)

 

1

rs10895875

11

q22.3

105785485

GRIA4

AA + AT

715 (64.6)

181 (69.1)

0.169

1.23 (0.92-1.64)

 

TT

392 (35.4)

81 (30.9)

 

1

rs4754136

11

q22.3

105846312

GRIA4

CC + CT

1102 (99.5)

261 (99.6)

0.877

1.18 (0.14-10.18)

 

TT

5 (0.5)

1 (0.4)

 

1

rs17104835

11

q22.3

105971356

GRIA4

CC + CT

447 (40.4)

104 (39.8)

0.839

0.97 (0.74-1.28)

 

TT

660 (59.6)

158 (60.2)

 

1

rs7750018

6

q24.3

146206595

GRM1

CC + CT

285 (25.7)

62 (23.7)

0.486

0.89 (0.65-1.23)

     

TT

822 (74.3)

200 (76.3)

 

1

rs362851

6

q24.3

146389448

GRM1

CC + CG

713 (64.4)

169 (64.5)

0.977

1.00 (0.76-1.33)

 

GG

394 (35.6)

93 (35.5)

 

1

rs2300631

6

q24.3

146428918

GRM1

AA + AG

828 (74.8)

192 (63.3)

0.613

0.92 (0.68-1.25)

 

GG

279 (25.2)

70 (26.7)

 

1

rs12023603

3

p21.2

51466999

GRM2

AA + AG

1076 (97.2)

253 (96.6)

0.583

0.81 (0.38-1.72)

 

GG

31 (2.8)

9 (3.4)

 

1

rs1983842

3

p21.2

51535259

GRM2

AA + AG

1070 (96.7)

253 (96.6)

0.940

0.97 (0.46-2.04)

 

GG

37 (3.3)

9 (3.4)

 

1

rs802441

7

q21.11

86657787

GRM3

CC + CT

1081 (97.6)

255 (97.3)

0.759

0.88 (0.38-2.04)

 

TT

26 (2.4)

7 (2.7)

 

1

rs802466

7

q21.11

86698122

GRM3

CC + CT

222 (20.0)

44 (16.8)

0.230

0.80 (0.56-1.15)

 

TT

885 (80.0)

218 (83.2)

 

rs12704286

7

q21.11

86745625

GRM3

AA + AG

364 (32.9)

91 (34.8)

0.567

1.09 (0.82-1.44)

 

GG

743 (67.1)

171 (65.2)

 

1

rs17697415

7

q21.11

86772500

GRM3

AA + AG

138 (12.5)

34 (13.0)

0.822

1.05 (0.70-1.57)

 

GG

969 (87.5)

228 (87.0)

 

1

rs1873254

6

p21.31

34058712

GRM4

AA + AG

518 (55.9)

150 (57.4)

0.096

1.26 (0.96-1.66)

 

GG

488 (44.1)

112 (42.6)

 

1

rs937039

6

p21.31

34075875

GRM4

AA + AG

1090 (98.5)

260 (99.2)

0.337

2.03 (0.47-8.83)

 

GG

17 (1.5)

2 (0.8)

 

1

rs1565361

6

p21.31

34089248

GRM4

CC + CT

503 (45.5)

117 (44.7)

0.819

0.97 (0.74-1.27)

 

TT

604 (54.5)

145 (55.3)

 

1

rs4106126

11

q14.2

88647181

GRM5

CC + CT

1093 (98.7)

256 (97.7)

0.214

0.55 (0.21-1.44)

 

TT

14 (1.3)

6 (2.3)

 

1

rs1391878

11

q14.2

88713212

GRM5

CC + CT

264 (23.9)

58 (22.1)

0.557

0.91 (0.66-1.25)

 

TT

843 (76.1)

204 (77.9)

 

1

rs12787863

11

q14.2

88810547

GRM5

AA + AG

447 (40.4)

110 (42.0)

0.634

1.07 (0.81-1.40)

 

GG

660 (59.6)

152 (58.0)

 

1

rs7126679

11

q14.2

89020677

GRM5

AA + AG

651 (58.9)

160 (61.1)

0.513

1.10 (0.83-1.44)

 

GG

455 (41.1)

102 (38.9)

 

1

rs2856354

5

q35.3

178978728

GRM6

AA + AG

1055 (95.3)

244 (93.1)

0.151

0.67 (0.38-1.16)

 

GG

52 (4.7)

18 (6.9)

 

1

rs10464073

5

q35.3

178982284

GRM6

AA + AG

1056 (95.4)

244 (93.1)

0.132

0.65 (0.38-1.14)

 

GG

51 (4.6)

18 (6.9)

 

1

rs17078880

5

q35.3

178983436

GRM6

CC + CT

1089 (98.4)

258 (98.5)

0.908

1.07 (0.36-3.18)

 

TT

18 (1.6)

4 (1.5)

 

1

rs2645341

5

q35.3

178984314

GRM6

AA + AG

1087 (98.2)

258 (98.5)

0.756

1.19 (0.40-3.50)

 

GG

20 (1.8)

4 (1.5)

 

1

rs6764411

3

p26.1

7101864

GRM7

AA + AC

927 (83.8)

211 (80.5)

0.202

0.80 (0.57-1.13)

 

CC

179 (16.2)

51 (19.5)

 

1

rs17697928

3

p26.1

7326084

GRM7

AA + AG

861 (77.7)

199 (80)

0.525

0.90 (0.66-1.24)

 

GG

246 (22.3)

51 (19.5)

 

1

rs779741

3

p26.1

7541915

GRM7

AA + AC

917 (82.8)

218 (83.2)

0.886

1.03 (0.72-1.47)

 

CC

190 (17.2)

44 (16.8)

 

1

rs1354405

3

p26.1

7690304

GRM7

AA + AG

1012 (91.4)

236 (90.1)

0.491

0.85 (0.54-1.34)

 

GG

95 (8.6)

26 (9.9)

 

1

rs712723

7

q31.33

126439090

GRM8

CC + CT

698 (63.0)

174 (66.4)

0.309

1.16 (0.87-1.54)

 

TT

409 (37.0)

88 (33.6)

 

1

rs17627206

7

q31.33

126793483

GRM8

AA + AG

110 (9.9)

28 (10.7)

0.717

1.08 (0.70-1.68)

 

GG

997 (90.1)

234 (89.3)

 

1

rs11563505

7

q31.33

127059729

GRM8

CC + CT

1086 (98.1)

258 (98.5)

0.687

1.25 (0.42-3.66)

 

TT

21 (1.9)

4 (1.5)

 

1

  1. GRIK, glutamate receptor, ionotropic, kainate; GRIA, glutamate receptor, ionotropic, AMPA; GRM, glutamate receptor, metabotropic, SNP, single nucleotide polymorphism; CI, confidence interval.
  2. p-values were obtained by chi-square test (2 x 2 table).
  3. Statistical significance was considered as p value <0.05.
  4. Physical position of individual SNPs was based on the NCBI Assembly database: GRCH38 version.