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Table 1 Genotype distribution of glutamate receptor family gene SNPs in Taiwanese KD patients and controls

From: Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms

SNP Chromosome Cytoband Physical position Nearest genes   Controls KD patients
  No. (%) No. (%) p value Odds ratio (95% CI)
rs466013 21 q21.3 29826390 GRIK1 TT + TC 507 (45.9) 131 (50.2) 0.205 1.19 (0.91-1.56)
  CC 599 (54.1) 130 (49.8)   1
rs425507 21 q21.3 29827658 GRIK1 GG + GA 507(45.8) 130 (49.6) 0.265 1.17 (0.89-1.53)
  AA 600 (54.2) 132 (50.4)   1
rs388700 21 q21.3 29830158 GRIK1 TT + TA 506 (45.7) 130 (49.6) 0.254 1.17 (0.89-1.53)
  AA 601 (54.3) 132 (50.4)   1
rs402280 21 q21.3 29835401 GRIK1 TT + TA 424 (38.3) 116 (44.3) 0.075 1.28 (0.97-1.68)
  AA 683 (61.7) 146 (55.7)   1
rs17816480 6 q16.3 101522140 GRIK2 TT + TC 201 (18.2) 48 (18.3) 0.951 1.01 (0.71-1.43)
  CC 906 (81.8) 214 (81.7)   1
rs2786239 6 q16.3 101637565 GRIK2 GG + GA 186 (16.8) 45 (17.2) 0.885 1.03 (0.72-1.47)
  AA 921 (83.2) 217 (82.8)  
rs4840194 6 q16.3 101768497 GRIK2 CC + CT 357 (32.2) 88 (33.6) 0.677 1.06 (0.80-1.41)
  TT 750 (67.8) 174 (66.4)   1
rs1310715 6 q16.3 101961427 GRIK2 TT + TC 597 (53) 133 (50.9) 0.468 0.91 (0.69-1.91)
  CC 520 (47.0) 128 (49.1)   1
rs527631 1 p34.3 36844396 GRIK3 AA + AG 172 (15.5) 45 (17.6) 0.407 1.16 (0.81-1.67)
  GG 935 (84.5) 210 (82.4)   1
rs476894 1 p34.3 36868682 GRIK3 GG + GA 234 (21.1) 63 (24.0) 0.305 1.18 (0.86-1.62)
  AA 873 (78.9) 199 (76.0)   1
rs541671 1 p34.3 36905238 GRIK3 TT + TA 267 (24.1) 65 (25.9) 0.554 1.10 (0.80-1.51)
  AA 840 (75.9) 186 (74.1)   1
rs35317705 1 p34.3 36972969 GRIK3 CC + CT 128 (11.6) 33 (12.6) 0.641 1.10 (0.73-1.66)
  TT 979 (88.4) 229 (87.4)   1
rs11218005 11 q23.3 120782227 GRIK4 AA + AC 132 (11.9) 35 (13.4) 0.523 1.14 (0.76-1.70)
  CC 975 (88.1) 227 (86.6)   1
rs3901285 11 q23.3 120862726 GRIK4 TT + TC 650 (58.7) 158 (60.3) 0.638 1.07 (0.81-1.41)
  CC 457 (41.3) 104 (39.7)   1
rs4936566 11 q23.3 120944529 GRIK4 AA + AG 669 (60.4) 145 (55.3) 0.131 0.81 (0.62-1.06)
  GG 438 (39.6) 117 (44.7)   1
rs443239 19 q13.2 42001892 GRIK5 CC + CG 289 (26.1) 64 (24.4) 0.576 0.91 (0.67-1.25)
  GG 818 (73.9) 198 (75.6)   1
rs1493395 5 q33.2 153532297 GRIA1 AA + AG 565 (51.1) 125 (47.7) 0.326 0.87 (0.67-1.14)
  GG 541 (48.9) 137 (52.3)   1
rs12153489 5 q33.2 153568777 GRIA1 CC + CT 1087 (98.2) 259 (98.9) 0.454 1.59 (0.47-5.39)
  TT 20 (1.8) 3 (1.1)   1
rs4424038 5 q33.2 153740704 GRIA1 CC + CT 1102 (99.5) 262 (100.0) 0.276 ND
  TT 5 (0.5) 0 (0.0)   1
rs17035909 4 q32.1 157247565 GRIA2 AA + AT 351 (31.7) 87 (33.3) 0.640 1.07 (0.80-1.43)
  TT 756 (68.3) 175 (66.7)   1
rs17035959 4 q32.1 157302204 GRIA2 AA + AC 1075 (97.1) 255 (97.3) 0.848 1.08 (0.47-2.48)
  CC 32 (2.9) 7 (2.7)   1
rs7695870 4 q32.1 157342624 GRIA2 CC + CT 1082 (97.7) 258 (98.5) 0.460 1.49 (0.51-4.32)
  TT 25 (2.3) 4 (1.5)   1
rs6855973 4 q32.1 157365463 GRIA2 AA + AT 1085 (98) 258 (98.4) 0.623 1.31 (0.45-3.83)
  TT 22 (2.0) 4 (1.6)   1
rs10895875 11 q22.3 105785485 GRIA4 AA + AT 715 (64.6) 181 (69.1) 0.169 1.23 (0.92-1.64)
  TT 392 (35.4) 81 (30.9)   1
rs4754136 11 q22.3 105846312 GRIA4 CC + CT 1102 (99.5) 261 (99.6) 0.877 1.18 (0.14-10.18)
  TT 5 (0.5) 1 (0.4)   1
rs17104835 11 q22.3 105971356 GRIA4 CC + CT 447 (40.4) 104 (39.8) 0.839 0.97 (0.74-1.28)
  TT 660 (59.6) 158 (60.2)   1
rs7750018 6 q24.3 146206595 GRM1 CC + CT 285 (25.7) 62 (23.7) 0.486 0.89 (0.65-1.23)
      TT 822 (74.3) 200 (76.3)   1
rs362851 6 q24.3 146389448 GRM1 CC + CG 713 (64.4) 169 (64.5) 0.977 1.00 (0.76-1.33)
  GG 394 (35.6) 93 (35.5)   1
rs2300631 6 q24.3 146428918 GRM1 AA + AG 828 (74.8) 192 (63.3) 0.613 0.92 (0.68-1.25)
  GG 279 (25.2) 70 (26.7)   1
rs12023603 3 p21.2 51466999 GRM2 AA + AG 1076 (97.2) 253 (96.6) 0.583 0.81 (0.38-1.72)
  GG 31 (2.8) 9 (3.4)   1
rs1983842 3 p21.2 51535259 GRM2 AA + AG 1070 (96.7) 253 (96.6) 0.940 0.97 (0.46-2.04)
  GG 37 (3.3) 9 (3.4)   1
rs802441 7 q21.11 86657787 GRM3 CC + CT 1081 (97.6) 255 (97.3) 0.759 0.88 (0.38-2.04)
  TT 26 (2.4) 7 (2.7)   1
rs802466 7 q21.11 86698122 GRM3 CC + CT 222 (20.0) 44 (16.8) 0.230 0.80 (0.56-1.15)
  TT 885 (80.0) 218 (83.2)  
rs12704286 7 q21.11 86745625 GRM3 AA + AG 364 (32.9) 91 (34.8) 0.567 1.09 (0.82-1.44)
  GG 743 (67.1) 171 (65.2)   1
rs17697415 7 q21.11 86772500 GRM3 AA + AG 138 (12.5) 34 (13.0) 0.822 1.05 (0.70-1.57)
  GG 969 (87.5) 228 (87.0)   1
rs1873254 6 p21.31 34058712 GRM4 AA + AG 518 (55.9) 150 (57.4) 0.096 1.26 (0.96-1.66)
  GG 488 (44.1) 112 (42.6)   1
rs937039 6 p21.31 34075875 GRM4 AA + AG 1090 (98.5) 260 (99.2) 0.337 2.03 (0.47-8.83)
  GG 17 (1.5) 2 (0.8)   1
rs1565361 6 p21.31 34089248 GRM4 CC + CT 503 (45.5) 117 (44.7) 0.819 0.97 (0.74-1.27)
  TT 604 (54.5) 145 (55.3)   1
rs4106126 11 q14.2 88647181 GRM5 CC + CT 1093 (98.7) 256 (97.7) 0.214 0.55 (0.21-1.44)
  TT 14 (1.3) 6 (2.3)   1
rs1391878 11 q14.2 88713212 GRM5 CC + CT 264 (23.9) 58 (22.1) 0.557 0.91 (0.66-1.25)
  TT 843 (76.1) 204 (77.9)   1
rs12787863 11 q14.2 88810547 GRM5 AA + AG 447 (40.4) 110 (42.0) 0.634 1.07 (0.81-1.40)
  GG 660 (59.6) 152 (58.0)   1
rs7126679 11 q14.2 89020677 GRM5 AA + AG 651 (58.9) 160 (61.1) 0.513 1.10 (0.83-1.44)
  GG 455 (41.1) 102 (38.9)   1
rs2856354 5 q35.3 178978728 GRM6 AA + AG 1055 (95.3) 244 (93.1) 0.151 0.67 (0.38-1.16)
  GG 52 (4.7) 18 (6.9)   1
rs10464073 5 q35.3 178982284 GRM6 AA + AG 1056 (95.4) 244 (93.1) 0.132 0.65 (0.38-1.14)
  GG 51 (4.6) 18 (6.9)   1
rs17078880 5 q35.3 178983436 GRM6 CC + CT 1089 (98.4) 258 (98.5) 0.908 1.07 (0.36-3.18)
  TT 18 (1.6) 4 (1.5)   1
rs2645341 5 q35.3 178984314 GRM6 AA + AG 1087 (98.2) 258 (98.5) 0.756 1.19 (0.40-3.50)
  GG 20 (1.8) 4 (1.5)   1
rs6764411 3 p26.1 7101864 GRM7 AA + AC 927 (83.8) 211 (80.5) 0.202 0.80 (0.57-1.13)
  CC 179 (16.2) 51 (19.5)   1
rs17697928 3 p26.1 7326084 GRM7 AA + AG 861 (77.7) 199 (80) 0.525 0.90 (0.66-1.24)
  GG 246 (22.3) 51 (19.5)   1
rs779741 3 p26.1 7541915 GRM7 AA + AC 917 (82.8) 218 (83.2) 0.886 1.03 (0.72-1.47)
  CC 190 (17.2) 44 (16.8)   1
rs1354405 3 p26.1 7690304 GRM7 AA + AG 1012 (91.4) 236 (90.1) 0.491 0.85 (0.54-1.34)
  GG 95 (8.6) 26 (9.9)   1
rs712723 7 q31.33 126439090 GRM8 CC + CT 698 (63.0) 174 (66.4) 0.309 1.16 (0.87-1.54)
  TT 409 (37.0) 88 (33.6)   1
rs17627206 7 q31.33 126793483 GRM8 AA + AG 110 (9.9) 28 (10.7) 0.717 1.08 (0.70-1.68)
  GG 997 (90.1) 234 (89.3)   1
rs11563505 7 q31.33 127059729 GRM8 CC + CT 1086 (98.1) 258 (98.5) 0.687 1.25 (0.42-3.66)
  TT 21 (1.9) 4 (1.5)   1
  1. GRIK, glutamate receptor, ionotropic, kainate; GRIA, glutamate receptor, ionotropic, AMPA; GRM, glutamate receptor, metabotropic, SNP, single nucleotide polymorphism; CI, confidence interval.
  2. p-values were obtained by chi-square test (2 x 2 table).
  3. Statistical significance was considered as p value <0.05.
  4. Physical position of individual SNPs was based on the NCBI Assembly database: GRCH38 version.