Figure 7

Detection of Neil1 and OGG1 in the remaining liver after PH. (A) Immunohistochemical staining for Neil1 (A) and OGG1 (B). Positively staining cells appear brown. Representative data of 3 or 4 individual samples per group. The number of Neil1 or OGG1 positive hepatocytes was significantly increased in WT mice or KO mice pretreated with IL-6 compared to KO mice after PH. (C) Western blot analysis confirmed the finding that expression of p21, Neil and OGG1 was increased only in WT mice or IL-6 KO mice with SC injection of IL-6. Each lane represents hepatic protein extracted from one animal at each time-point.