Figure 2
From: miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts
miRNA expressions during unfolded protein response in H9c2 cardiomyocytes. (A) Heat map summarizing the expression of miRNAs. Each column represents 1 of the samples, and each row represents 1 of 86 differentially expressed miRNAs at P <0.05. Samples were grouped by treatments, and miRNAs arranged by unsupervised hierarchical clustering. Red and green indicate up and downregulation, respectively, relative to the overall mean for each miRNA. Control-1 and control-2, untreated H9c2 cells; Tg-1 and Tg-2, thapsigargin treated H9c2 cells; Tm-1 and Tm-2, tunicamycin treated H9c2 cells. (B) Expression pattern of top 10 miRNAs (in terms of fluorescence intensity) upregulated upon treatment with thapsigargin and tunicamycin in H9c2 cells. (C) Expression pattern of top 10 miRNAs (in terms of fluorescence intensity) downregulated upon treatment with thapsigargin and tunicamycin in H9c2 cells.