Table 3 Univariate and multivariate analysis of association of clinicopathologic features with survival time
From: Integrin αvβ6 and transcriptional factor Ets-1 act as prognostic indicators in colorectal cancer
Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
Relative risk | 95% CI | P value | Relative risk | 95% CI | P value | |
Age at diagnosis | 0.996 | 0.980,1.011 | 0.583 | |||
Gender | ||||||
Male | 1.000(Ref.) | - | - | |||
Female | 1.053 | 0.651,1,702 | 0.834 | |||
Location | ||||||
Colon | 1.000(Ref.) | - | - | |||
Rectum | 1.014 | 0.628,1.638 | 0.953 | |||
Tumor size | 0.064 | |||||
<2 cm | 1.000(Ref.) | - | - | |||
2 ~ 5 cm | 0.592 | 0.282,1.245 | 0.167 | |||
>5 cm | 1.356 | 0.798,2.302 | 0.260 | |||
Duke’s phase | ||||||
A + B | 1.000(Ref.) | - | - | |||
C + D | 1.460 | 0.877,2.432 | 0.146 | |||
T stage | 0.386 | |||||
T1 | 1.000(Ref.) | - | - | |||
T2 | 1938.169 | 0.000,>10 5 | 0.912 | |||
T3 | 2612.435 | 0.000,>10 5 | 0.909 | |||
T4 | 3765.785 | 0.000,>10 5 | 0.905 | |||
N stage | 0.010 | 0.721 | ||||
N0 | 1.000(Ref.) | - | - | 1.000(Ref.) | - | - |
N1 | 2.202 | 1.302,3.727 | 0.003 | 0.697 | 0.261,1.859 | 0.470 |
N2 | 1.845 | 0.921,3.696 | 0.084 | 0.649 | 0.221,1.903 | 0.431 |
M stage | ||||||
M0 | 1.000(Ref.) | - | - | 1.000(Ref.) | - | - |
M1 | 3.430 | 2.019,5.828 | <0.001 | 1.998 | 0.432,9.235 | 0.376 |
TNM stage | <0.001 | 0.709 | ||||
I | 1.000(Ref.) | - | - | 1.000(Ref.) | - | - |
II | 1.421 | 0.427,4.734 | 0.567 | 1.599 | 0.479,5.341 | 0.446 |
III | 2.697 | 0.804,9.049 | 0.108 | 1.846 | 0.384,8.887 | 0.444 |
IV | 6.005 | 1.777,20.296 | 0.004 | # | # | # |
Differentiation | 0.257 | |||||
Well | 1.000(Ref.) | - | - | 1.000(Ref.) | - | - |
Moderate | 1.606 | 0.802,3.216 | 0.181 | |||
Poor/unknown | 1.794 | 0.889,3.620 | 0.103 | |||
Ets-1 | ||||||
Negative | 1.000(Ref.) | - | - | 1.000(Ref.) | - | - |
Positive | 4.913 | 2.792,8.645 | <0.001 | 3.903 | 1.945,7.832 | <0.001 |
αvβ6 | ||||||
Negative | 1.000(Ref.) | - | - | 1.000(Ref.) | - | - |
Positive | 3.775 | 2.324,6.133 | <0.001 | 2.175 | 1.190,3.974 | 0.012 |