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Table 3 Univariate and multivariate analysis of association of clinicopathologic features with survival time

From: Integrin αvβ6 and transcriptional factor Ets-1 act as prognostic indicators in colorectal cancer

Variable Univariate analysis Multivariate analysis
  Relative risk 95% CI P value Relative risk 95% CI P value
Age at diagnosis 0.996 0.980,1.011 0.583    
Gender       
 Male 1.000(Ref.) - -    
 Female 1.053 0.651,1,702 0.834    
Location       
 Colon 1.000(Ref.) - -    
 Rectum 1.014 0.628,1.638 0.953    
Tumor size    0.064    
 <2 cm 1.000(Ref.) - -    
 2 ~ 5 cm 0.592 0.282,1.245 0.167    
 >5 cm 1.356 0.798,2.302 0.260    
Duke’s phase       
 A + B 1.000(Ref.) - -    
 C + D 1.460 0.877,2.432 0.146    
T stage    0.386    
 T1 1.000(Ref.) - -    
 T2 1938.169 0.000,>10 5 0.912    
 T3 2612.435 0.000,>10 5 0.909    
 T4 3765.785 0.000,>10 5 0.905    
N stage    0.010    0.721
 N0 1.000(Ref.) - - 1.000(Ref.) - -
 N1 2.202 1.302,3.727 0.003 0.697 0.261,1.859 0.470
 N2 1.845 0.921,3.696 0.084 0.649 0.221,1.903 0.431
M stage       
 M0 1.000(Ref.) - - 1.000(Ref.) - -
 M1 3.430 2.019,5.828 <0.001 1.998 0.432,9.235 0.376
TNM stage    <0.001    0.709
 I 1.000(Ref.) - - 1.000(Ref.) - -
 II 1.421 0.427,4.734 0.567 1.599 0.479,5.341 0.446
 III 2.697 0.804,9.049 0.108 1.846 0.384,8.887 0.444
 IV 6.005 1.777,20.296 0.004 # # #
Differentiation    0.257    
 Well 1.000(Ref.) - - 1.000(Ref.) - -
 Moderate 1.606 0.802,3.216 0.181    
 Poor/unknown 1.794 0.889,3.620 0.103    
Ets-1       
 Negative 1.000(Ref.) - - 1.000(Ref.) - -
 Positive 4.913 2.792,8.645 <0.001 3.903 1.945,7.832 <0.001
αvβ6       
 Negative 1.000(Ref.) - - 1.000(Ref.) - -
 Positive 3.775 2.324,6.133 <0.001 2.175 1.190,3.974 0.012
  1. #: TNM stage IV is linearly dependent on M stage M1.