Proliferative ductular reactions correlate with hepatic progenitor cell and predict recurrence in HCC patients after curative resection

Table 4 Univariate and multivariate analyses of factors associated with survival and recurrence in hepatocellular carcinoma group of testing cohort (n = 120)

Factors			Overall Survival (OS)		Disease-free Survival (DFS)
		Univariate	Multivare		Univariate	Multivariate
		P	HR (95% CI)	P	P	HR (95% CI)	P
Characteristic of	Age: >50 vs. ≤50 years*	0.719		NA	0.981		NA
Demography,	Gender: male vs. female	0.846		NA	0.088		NA
Tumor &	Tumor size: >5 vs. ≤5 cm	0.061		NA	0.130		NA
Laboratory	Tumor number: multiple vs. single	0.221		NA	0.192		NA
Tests	Serum AFP: ≥400 vs. <400 ng/ml	0.285		NA	0.382		NA
	Serum CA199 ≥ 37 vs. < 37 U/ml	0.798		NA	0.236		NA
	TNM stage: I/II vs. III	0.030*		NS	0.001*	1.817 (1.135-2.909)	0.013*
	Edmondson grade: I/II vs. III/IV	0.074		NA	0.043*		NS
	Macrovascular Invasion: P vs. N	0.014*		NS	0.114		NA
	Tumor encapsulation: absence vs. presence	0.791		NA	0.311		NA
Histology:	Ishak grade >7 vs. ≤ 7	0.058		NA	0.072		NA
Peritumor	Ishak stage >5 vs. ≤ 5	0.096		NA	0.120		NA
	PI-DR ≥ 50% vs. <50%	<0.001*	3.316(1.961-5.610)	<0.001*	<0.001*	2.618(1.701-4.029)	<0.001*
	K7-DR ≥ 50% vs. <50%	0.045*	1.863(1.008-3.443)	0.047*	0.158		NA
	EpCAM^Peritumor Expression H vs. L*	0.319		NA	0.003*		NS
	OV6^Peritumor Expression H vs. L*	0.191		NA	0.702		NA
	C-kit^PeritumorExpression H vs. L*	0.721		NA	0.935		NA
	CD133^Peritumor Expression H vs. L*	0.051		NA	<0.001*		NS
Histology:	Microvascular invasion: P vs. N	0.327		NA	0.595		NA
Tumor:	EpCAM Expression H vs. L*	0.017*		NS	0.093		NA
	OV6 Expression H vs. L*	0.756		NA	0.034*		NS
	C-kit Expression H vs. L*	0.352		NA	0.127		NA
	CD133 Expression H vs. L*	0.394		NA	0.091		NA

P, positive; N, negative; H, High; L, Low; NA, not adopted; NS, not significant;AFP, alpha-fetoprotein; ALT, alanine aminotransferase; CA 19-9, carbohydrate antigen 19–9; CI, confidence interval; PI-DR, proliferative index of ductular reaction; DR, ductular reaction; EpCAM, epithelial cell adhesion molecule; HCC, hepatocellular carcinoma; HR, hazard ratio; K7-DR, Keratin 7 immunoreactive ductular reaction; TNM, tumor-node-metastasis;
*Medians were used for cutoff values.

ISSN: 2045-3701