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Table 4 Univariate and multivariate analyses of factors associated with survival and recurrence in hepatocellular carcinoma group of testing cohort (n = 120)

From: Proliferative ductular reactions correlate with hepatic progenitor cell and predict recurrence in HCC patients after curative resection

Factors   Overall Survival (OS) Disease-free Survival (DFS)
Univariate Multivare Univariate Multivariate
P HR (95% CI) P P HR (95% CI) P
Characteristic of Age: >50 vs. ≤50 years* 0.719   NA 0.981   NA
Demography, Gender: male vs. female 0.846   NA 0.088   NA
Tumor & Tumor size: >5 vs. ≤5 cm 0.061   NA 0.130   NA
Laboratory Tumor number: multiple vs. single 0.221   NA 0.192   NA
Tests Serum AFP: ≥400 vs. <400 ng/ml 0.285   NA 0.382   NA
  Serum CA199 ≥ 37 vs. < 37 U/ml 0.798   NA 0.236   NA
  TNM stage: I/II vs. III 0.030*   NS 0.001* 1.817 (1.135-2.909) 0.013*
  Edmondson grade: I/II vs. III/IV 0.074   NA 0.043*   NS
  Macrovascular Invasion: P vs. N 0.014*   NS 0.114   NA
  Tumor encapsulation: absence vs. presence 0.791   NA 0.311   NA
Histology: Ishak grade >7 vs. ≤ 7 0.058   NA 0.072   NA
Peritumor Ishak stage >5 vs. ≤ 5 0.096   NA 0.120   NA
  PI-DR ≥ 50% vs. <50% <0.001* 3.316(1.961-5.610) <0.001* <0.001* 2.618(1.701-4.029) <0.001*
  K7-DR ≥ 50% vs. <50% 0.045* 1.863(1.008-3.443) 0.047* 0.158   NA
  EpCAMPeritumor Expression H vs. L* 0.319   NA 0.003*   NS
  OV6Peritumor Expression H vs. L* 0.191   NA 0.702   NA
  C-kitPeritumorExpression H vs. L* 0.721   NA 0.935   NA
  CD133Peritumor Expression H vs. L* 0.051   NA <0.001*   NS
Histology: Microvascular invasion: P vs. N 0.327   NA 0.595   NA
Tumor: EpCAM Expression H vs. L* 0.017*   NS 0.093   NA
  OV6 Expression H vs. L* 0.756   NA 0.034*   NS
  C-kit Expression H vs. L* 0.352   NA 0.127   NA
  CD133 Expression H vs. L* 0.394   NA 0.091   NA
  1. P, positive; N, negative; H, High; L, Low; NA, not adopted; NS, not significant;AFP, alpha-fetoprotein; ALT, alanine aminotransferase; CA 19-9, carbohydrate antigen 19–9; CI, confidence interval; PI-DR, proliferative index of ductular reaction; DR, ductular reaction; EpCAM, epithelial cell adhesion molecule; HCC, hepatocellular carcinoma; HR, hazard ratio; K7-DR, Keratin 7 immunoreactive ductular reaction; TNM, tumor-node-metastasis;
  2. *Medians were used for cutoff values.