Proliferative ductular reactions correlate with hepatic progenitor cell and predict recurrence in HCC patients after curative resection

Table 3 Immunohistochemical stain results and clinicopathologic features in intratumoral tissue of 120 HCCs

Clinicopathologic features	Intratumoral EpCAM density		P Value	Intratumoral OV6 density		P Value	Intratumoral CD133 density		P Value	Intratumoral c-kit density		P Value
Clinicopathologic features	High	Low	P Value	High	Low	P Value	High	Low	P Value	High	Low	P Value
Frequency (%)	39 (32.5%)	81 (67.5%)		26 (21.7%)	94 (78.3%)		29 (24.2%)	91 (75.8%)		34 (28.3%)	86 (71.7%)
Gender
Male	34	74	0.697	21	87	0.161	26	82	1.000	32	76	0.543
Female	5	7		5	7		3	9		2	10
Age
≤60	19	44	0.565	19	62	0.493	13	50	0.342	19	44	0.641
>60	20	37		7	32		16	41		15	42
AFP
≤400	17	64	<0.001*	19	62	0.493	20	61	0.847	23	58	0.983
>400	22	17		7	32		9	30		11	28
Cirrhosis
Absence	21	50	0.411	10	61	0.015*	14	57	0.171	17	54	0.199
Presence	18	31		16	33		15	34		17	32
Satellite lesion
Absence	33	72	0.507	22	83	0.867	27	78	0.468	33	72	0.092
Presence	6	9		4	11		2	13		1	14
Tumor size (cm)
≤5cm	15	37	0.455	14	38	0.222	13	39	0.852	12	40	0.264
>5cm	24	44		12	56		16	52		22	46
Tumor encapsulation
Absence	26	61	0.321	18	69	0.673	19	68	0.334	27	60	0.286
Presence	13	20		8	25		10	23		7	26
Microvascular invasion
Absence	15	40	0.261	14	41	0.354	12	43	0.580	17	38	0.565
Presence	24	41		12	53		17	48		17	48
Major vascular invasion
Absence	34	80	0.023*	25	89	1.000	28	86	1.000	32	82	1.000
Presence	5	1		1	5		1	5		2	4
Edmondson grade
Low (I/II)	23	67	0.005*	17	73	0.201	19	71	0.176	20	70	0.010*
High (III/IV)	16	14		9	21		10	20		14	16
TNM stage
I/II	27	65	0.181	17	75	0.124	20	72	0.260	28	64	0.354
III	12	16		9	19		9	19		6	22

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