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Table 3 Immunohistochemical stain results and clinicopathologic features in intratumoral tissue of 120 HCCs

From: Proliferative ductular reactions correlate with hepatic progenitor cell and predict recurrence in HCC patients after curative resection

Clinicopathologic features Intratumoral EpCAM density P Value Intratumoral OV6 density P Value Intratumoral CD133 density P Value Intratumoral c-kit density P Value
High Low High Low High Low High Low
Frequency (%) 39 (32.5%) 81 (67.5%)   26 (21.7%) 94 (78.3%)   29 (24.2%) 91 (75.8%)   34 (28.3%) 86 (71.7%)  
Gender             
Male 34 74 0.697 21 87 0.161 26 82 1.000 32 76 0.543
Female 5 7   5 7   3 9   2 10  
Age             
≤60 19 44 0.565 19 62 0.493 13 50 0.342 19 44 0.641
>60 20 37   7 32   16 41   15 42  
AFP             
≤400 17 64 <0.001* 19 62 0.493 20 61 0.847 23 58 0.983
>400 22 17   7 32   9 30   11 28  
Cirrhosis             
Absence 21 50 0.411 10 61 0.015* 14 57 0.171 17 54 0.199
Presence 18 31   16 33   15 34   17 32  
Satellite lesion             
Absence 33 72 0.507 22 83 0.867 27 78 0.468 33 72 0.092
Presence 6 9   4 11   2 13   1 14  
Tumor size (cm)             
≤5cm 15 37 0.455 14 38 0.222 13 39 0.852 12 40 0.264
>5cm 24 44   12 56   16 52   22 46  
Tumor encapsulation             
Absence 26 61 0.321 18 69 0.673 19 68 0.334 27 60 0.286
Presence 13 20   8 25   10 23   7 26  
Microvascular invasion             
Absence 15 40 0.261 14 41 0.354 12 43 0.580 17 38 0.565
Presence 24 41   12 53   17 48   17 48  
Major vascular invasion             
Absence 34 80 0.023* 25 89 1.000 28 86 1.000 32 82 1.000
Presence 5 1   1 5   1 5   2 4  
Edmondson grade             
Low (I/II) 23 67 0.005* 17 73 0.201 19 71 0.176 20 70 0.010*
High (III/IV) 16 14   9 21   10 20   14 16  
TNM stage             
I/II 27 65 0.181 17 75 0.124 20 72 0.260 28 64 0.354
III 12 16   9 19   9 19   6 22  
  1. *p <0 .05 was considered statistically significant.