SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma

Table 1 Correlation of clinicopathologic characteristics with SIRT1 protein, VEGF-C protein, LVD and LVI

Variables	SIRT1		P	VEGF-C		P	LVD		P	LVI		P
Variables	Negative (n = 111)	Positive (n = 95)	P	Negative (n = 99)	Positive (n = 107)	P	Low (n = 123)	High (n = 83)	P	Negative (n = 135)	Positive (n = 71)	P
Gender			0.975			0.516			0.171			0.897
Male	82	70		71	81		95	57		100	52
Female	29	25		28	26		28	26		35	19
Age (year)			0.697			0.786			0.842			0.327
<50	30	28		27	31		34	24		35	23
≥50	81	67		72	76		89	59		100	48
Weight loss (kg)			0.205			0.834			0.940			0.239
<2.5	67	49		55	61		69	47		80	36
≥2.5	44	46		44	46		54	36		55	35
Length of tumor (cm)			0.654			0.492			0.991			0.980
<3	45	43		45	43		53	35		58	30
3-5	55	41		42	54		57	39		63	33
>5	11	11		12	10		13	9		14	8
Differentiation			0.070			0.125			0.294			0.027
Well	27	13		25	15		28	12		30	10
Moderate	56	62		53	65		69	49		81	37
Poor	28	20		21	27		26	22		24	24
Tumor location			0.227			0.083			0.765			0.370
Upper	17	8		17	8		16	9		19	6
Middle	56	57		49	64		65	48		70	43
Lower	38	30		33	35		42	26		46	22
T status			<0.001			0.025			0.439			0.036
T1	26	7		23	10		23	10		26	7
T2	63	47		48	62		64	46		75	35
T3	22	41		28	35		36	27		34	29
Stage			0.001			0.001			0.069			0.039
I	30	13		31	12		32	11		35	8
IIa	47	28		35	40		44	31		48	27
IIb	34	54		33	55		47	41		52	36

ISSN: 2045-3701