Table 2 Regulation of DNMT expression by miRNAs
From: Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer
Pathway | Regulated regions | DNMTs | Cancer types | References |
|---|---|---|---|---|
miR-16c | 3'-UTRs | DNMT3B | in vitro | [80] |
miR-26b | ND | DNMT3B | breast cancer | [78] |
miR-29a | 3'-UTRs | DNMT3A/3B | lung cancer | [73] |
miR-29b | 3'-UTRs | DNMT1/3A/3B | lung, ALL and melanomas | |
miR-29c | 3'-UTRs | DNMT3A/3B | breast, lung and melanomas | |
miR-143 | 3'-UTRs | DNMT3A | colorectal | [79] |
miR-148a | ND | DNMT1 | lung and pancreas | |
miR-148b | ND | DNMT3B | breast cancer | [78] |
miR-152 | ND | DNMT1 | pancreas | [77] |
miR-222 | 3'-UTRs | DNMT3B | in vitro | [80] |
miR-1632 | 3'-UTRs | DNMT3B | in vitro | [80] |
miR-1741 | 3'-UTRs | DNMT3A | in vitro | [80] |