From: Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer
Pathways | Mechanisms | DNMTs mRNA/promoters | References |
---|---|---|---|
Down regulation | Â | Â | Â |
p53 | p53/Sp1 transcriptional repression | DNMT1/3A/3B | [32] |
RB/E2F | RB/E2F transcriptional repression | DNMT1/3A | |
FOXO3a | Transcriptional repression | DNMT3B | [37] |
Up regulation | Â | Â | Â |
Ras/AP-1 | AP1 transcriptional activation | DNMT1 | |
Sp1 | Transcriptional activation | DNMT1/3A/3B | |
Sp3 | Transcriptional activation | DNMT1/3A/3B | |
E2F | Transcriptional activation | DNMT1 | |
ERK | Unknow | DNMT1/3A | [40] |
17β-estradiol | ER-dependent transcription activation | DNMT3B | [41] |
Homeobox B3 | Promoter binding | DNMT3B | [31] |
Wilms' tumour 1 | Transcriptional activation | DNMT3A | [30] |
Viruse induction | Â | Â | Â |
LMP1 | Activation of JNK/AP-1 pathway | DNMT1 | [42] |
BKV Tag and E1a | pRB/E2F pathway | DNMT1 | [43] |
HBx | Promoter transcriptional activator | DNMT1/3A | [44] |
HBx | Promoter transcriptional repression | DNMT3b | [44] |
HIV-1 | Through transcription factor AP-1 | DNMT1 | [45] |