Figure 2
From: Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer
Acetylation-mediated DNMT stability and activity. (A) Tip60 promotes acetylation of DNMT1, which triggers ubiquitination by the E3 ligase UHRF1, thereby targeting DNMT1 for proteasomal degradation. (B) RGS6 serves as a scaffold to facilitate Tip60 acetylation of DNMT1 and subsequent DNMT1 degradation. (C) Deacetylation of Lys1349 and Lys1415 by SIRT1 in the catalytic domain of DNMT1 enhances the methyltransferase activity of DNMT1.