Ring finger protein 39 genetic variants associate with HIV-1 plasma viral loads and its replication in cell culture

Table 2 Effects of RNF39 gene SNPs on plasma HIV-1 viral load in the Han Chinese Population in Taiwan

Gene	Location	Position	SNP		Genotype	Taiwanese HIV-1 infected patients
Gene	Location	Position	SNP		Genotype	Genotype frequency (No (%))	HIV-1 Viral Load (log10 copies/mL, mean (interquartile range))^a	p-value^b
RNF39	5′ near gene	30,043,779	SNP1	rs3807032	GG*	219 (72.3)	3.9 (2.6–6.4)	0.002*
					CG + CC	74 (24.4) + 10 (3.3)	4.2 (2.6–5.8)
	5′ near gene	30,043,955	SNP2	rs3807033	GG*	220 (72.6)	3.9 (2.6–6.4)	0.002*
					AG + AA	73 (24.1) + 10 (3.3)	4.2 (2.6–5.8)
	5′ near gene	30,044,388	SNP3	rs3132682	CC*	95 (31.4)	3.9 (2.6–5.3)	0.299
					CG + GG	127 (41.9) + 81 (26.7)	4.0 (2.6–6.4)
	5′ near gene	30,044,827	SNP4	rs3807035	GG*	202 (66.7)	3.9 (2.6–6.4)	0.034
					AG + AA	89 (29.4) + 12 (4.0)	4.1 (2.6–5.8)
	5′ near gene	30,044,914	SNP5	rs3807036	GG*	283 (93.4)	4.0 (2.6–6.4)	0.199
					AG + AA	20 (6.6) + 0 (0.0)	3.7 (2.6–4.8)
	5′ near gene	30,045,199	SNP6	rs1150735	GG*	159 (52.5)	3.9 (2.6–5.3)	0.837
					AG + AA	114 (37.6) + 30 (9.9)	4.0 (2.6–6.4)

The asterisk and bold, emphasizing statistical significance at p < 0.0083 (0.05/6).
^aThe HIV-1 viral load was measured in the peripheral blood when the patient was examined with the earliest HIV-1 antibody positive result. Any measurements taken after the initiation of antiretroviral therapy were not used in any analyses.
^bp-values were obtained using the unpaired Student’s t-test.

ISSN: 2045-3701