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Table 2 Effects of RNF39 gene SNPs on plasma HIV-1 viral load in the Han Chinese Population in Taiwan

From: Ring finger protein 39 genetic variants associate with HIV-1 plasma viral loads and its replication in cell culture

Gene Location Position SNP Genotype Taiwanese HIV-1 infected patients
Genotype frequency (No (%)) HIV-1 Viral Load (log10 copies/mL, mean (interquartile range))a p-valueb
RNF39 5′ near gene 30,043,779 SNP1 rs3807032 GG* 219 (72.3) 3.9 (2.6–6.4) 0.002*
      CG + CC 74 (24.4) + 10 (3.3) 4.2 (2.6–5.8)  
  5′ near gene 30,043,955 SNP2 rs3807033 GG* 220 (72.6) 3.9 (2.6–6.4) 0.002*
      AG + AA 73 (24.1) + 10 (3.3) 4.2 (2.6–5.8)  
  5′ near gene 30,044,388 SNP3 rs3132682 CC* 95 (31.4) 3.9 (2.6–5.3) 0.299
      CG + GG 127 (41.9) + 81 (26.7) 4.0 (2.6–6.4)  
  5′ near gene 30,044,827 SNP4 rs3807035 GG* 202 (66.7) 3.9 (2.6–6.4) 0.034
      AG + AA 89 (29.4) + 12 (4.0) 4.1 (2.6–5.8)  
  5′ near gene 30,044,914 SNP5 rs3807036 GG* 283 (93.4) 4.0 (2.6–6.4) 0.199
      AG + AA 20 (6.6) + 0 (0.0) 3.7 (2.6–4.8)  
  5′ near gene 30,045,199 SNP6 rs1150735 GG* 159 (52.5) 3.9 (2.6–5.3) 0.837
      AG + AA 114 (37.6) + 30 (9.9) 4.0 (2.6–6.4)  
  1. The asterisk and bold, emphasizing statistical significance at p < 0.0083 (0.05/6).
  2. aThe HIV-1 viral load was measured in the peripheral blood when the patient was examined with the earliest HIV-1 antibody positive result. Any measurements taken after the initiation of antiretroviral therapy were not used in any analyses.
  3. bp-values were obtained using the unpaired Student’s t-test.