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Figure 6 | Cell & Bioscience

Figure 6

From: Comparative analysis of the activation of unfolded protein response by spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus HKU1

Figure 6

Mapping of UPR-activating domain in SARS-CoV and HCoV-HKU1 S proteins. (A) Truncated mutants. SARS-CoV (SCV) S protein and its truncated mutants S1 (amino acids 1–770), S2 (amino acids 771–1255), S1-M1 (amino acids 201–770), S1-M2 (amino acids 401–770) and S1-M3 (amino acids 534–770) as well as HCoV-HKU1 S protein and its truncated mutants S1 (amino acids 1–869) and S2 (amino acids 870–1356) were expressed in 293FT cells. (B-E) Luciferase reporter assay. S protein and its truncated mutants in escalating doses were compared for the activity to activate luciferase reporter expression driven by Grp78 and Grp94 promoters.

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Cell & Bioscience

ISSN: 2045-3701

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