Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Figure 1 | Cell & Bioscience

Figure 1

From: Diabetic macular edema: new concepts in patho-physiology and treatment

Figure 1

The inner blood retinal barrier and tight junction proteins. Three integral proteins form tight junction complexes: occludin, claudins and junctional adhesion molecules (JAMs) & endothelial cell-selective adhesion molecule (ESAM). Tricellulin is a recently discovered tightjunction protein that contributes to the structure and function of tricellular contacts of neighboring cells in many epithelial tissues Occludin and claudins are trans-membrane proteins, predicted to have four trans-membrane and two extra-cellular domains, which are the major structural components of tight junction strands. There are also a group of proteins named membrane-associated guanylate kinase homologs that are positioned on the cytoplasmic surface of junctional contacts. Zonula occludens (ZO) belongs to the MAGUKs family and is thought to interact with occlude.

Back to article page