Figure 1

Skin histopathology evaluation. A. ADSCs or fractional CO₂ laser treatment improved dermal thickness in the photoaging skin induced by UVB irradiation. B. V&G staining shows the light red collagen fibers(* indicate) decreased,dyeing shallowed,especially in the superficial layer dermis,however,the dark red elastic fiber(arrows indicate) increased, thicker, partial hyperplastic elastic fibers were fractured and snarling after UVB irradiation. ×400. Scale bars are 100 μm. C. fibers were stianed red,and that improved the enlarged diameter metamorphic fizzy fibers with infiltration of inflammatory cells in ADSC transplantation group (c,d) and CO₂ fractional laser treatment group (g,h). The improvement effect was significantly increased in combined treatment group (e,f). H&E × 400. Scale bars are 100 μm.