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Table 3 Univariate and multivariate analysis of association of clinicopathologic features with 5-year survival in colon cancer cases

From: Protein expression of eIF4E and integrin αvβ6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction

Variable Univariate analysis Multivariate analysis
  Relative risk 95% CI P Value Relative risk 95% CI P Value
Age at diagnosis 1.091 1.063, 1.119 <0.001 1.114 1.083, 1.145 <0.001
Gender       
 Male 1.000(Ref.) - -    
 Female 0.729 0.438, 1.212 0.223    
Tumor anatomical location       
 Right hemicolon cancer 1.000(Ref.) - -    
 Left hemicolon cancer 1.000 0.610,1.640 0.999    
T stage       
 T1 0.000 0.000, >105 0.973    
 T2 0.951 0.395, 2.290 0.910    
 T3 1.152 0.685, 1.937 0.595    
 T4 1.000(Ref.) - -    
N stage       
 N0 1.000(Ref.) - -    
 N1 1.308 0.760, 2.252 0.332    
 N2 1.356 0.646, 2.843 0.421    
M stage       
 M0 1.000(Ref.) - -    
 M1 1.308 0.697, 2.454 0.403    
TNM stage       
 I 1.000(Ref.) - -    
 II 0.634 0.242, 1.664 0.355    
 III 0.998 0.378, 2.638 0.997    
 IV 1.029 0.362, 2.922 0.957    
Pathology Grade       
 Well 1.000(Ref.) - - 1.000(Ref.) - -
 Moderate 1.666 0.912, 3.046 0.097 1.348 0.721, 2.519 0.349
 Poor/undifferentiated 1.845 0.950, 3.583 0.070 2.915 1.453, 5.848 0.003
eIF4E       
 Low expression 1.000(Ref.) - - 1.000(Ref.) - -
 High expression 1.885 1.128, 3.150 0.016 2.417 1.413, 4.134 0.001
αvβ6       
 Negative 1.000(Ref.) - - 1.000(Ref.) - -
 Positive 1.741 1.061, 2.857 0.028 2.393 1.421, 4.028 0.001