Passive systemic anaphylaxis in wild-type and SRC-3-/-mice. SRC-3+/+ (n = 5) and SRC-3-/- mice (n = 5) were sensitized with anti-DNP IgE and DNP-HSA to induced systemic anaphylaxis as described in methods. Passive systemic anaphylaxis was monitored by measuring rectal temperatures after DNP-HSA challenge. Data represent the mean rectal temperature ± SD. *p<0.05 versus SRC-3+/+ mice by t-test.