From: Open conformation of hERG channel turrets revealed by a specific scorpion toxin BmKKx2
hERG mutant | IC50a | nb | IC50(mut)/IC50(wt) |
---|---|---|---|
nM | |||
Wild Type | 6.7 ± 1.7 | 7 | 1.0 |
H578A | N.Ec | 5 | -e |
D580A | L.Ed | 5 | - |
R582A | 76.5 ± 32.6 | 4 | 11.4 |
I583A | 87.5 ± 16.8 | 4 | 13.1 |
W585A | N.E | 6 | - |
L586A | 24.3 ± 8.4 | 4 | 3.6 |
H587A | 59.7 ± 31.7 | 5 | 8.9 |
N588A | 14.5 ± 4.3 | 4 | 2.2 |
L589A | L.E | 6 | - |
D591A | 19.6 ± 1.7 | 4 | 2.9 |
Q592A | 89.5 ± 39.8 | 5 | 13.4 |
K595A | 65.2 ± 19.1 | 5 | 9.7 |
P596A | 60.8 ± 23.4 | 4 | 9.1 |
Y597A | 118.2 ± 26.7 | 4 | 17.6 |
N598A | 15.2 ± 4.8 | 4 | 2.3 |
S600A | 12.1 ± 3.5 | 4 | 1.8 |
K608A | 116.1 ± 29.2 | 5 | 17.3 |
D609A | L.E. | 8 | - |
K610A | 6.7 ± 5.1 | 5 | 1.0 |
T613A | 42.6 ± 17.1 | 5 | 6.4 |
N629A | L.E | 7 | - |
S631A | 698.0 ± 64.4 | 5 | 104.2 |