Skip to main content

Table 1 The binding affinities of wild-type BmKKx2 and its mutants towards hERG channel

From: Open conformation of hERG channel turrets revealed by a specific scorpion toxin BmKKx2

BmKKx2 mutant IC50a n b IC50(mut)/IC50(wt)
  nM   
Wild type 26.7 ± 1.7 6 1.0
R1A 238.3 ± 11.2 4 8.1
Y11A 131.0 ± 35.2 4 27.9
K18A 376.6 ± 62.0 6 80.1
R20A 409.6 ± 56.9 5 87.1
F21A 863.4 ± 73.4 5 183.7
K23A 123.2 ± 56.3 4 26.2
R27A 262.7 ± 25.9 4 13.3
F32A 24.1 ± 1.9 4 0.9
  1. aIC50 value(half-maximum inhibition concentration) represents as Mean ± Standard Error.
  2. bnumber of independent experiments.