Table 3 Anti-proliferative and pro-apoptotic functions of PXR
From: Tissue-specific regulation of pregnane X receptor in cancer development and therapy
Anti-proliferative functions of PXR | ||
|---|---|---|
Tissue specification | PXR activation approach | References |
Colon cancer | Ectopic expression of PXR significantly inhibited anchorage-independent growth and cell proliferation in vitro and xenograft tumor growth in vivo via G0/G1 cell-cycle arrest. | [50] |
Liver and colon carcinogenic tissue | PXR overexpression sensitized cells to paraquat-induced oxidative stress when treated with PXR agonists. | [51] |
Pro-apoptotic functions of PXR | ||
Tissue specification | PXR activation approach | Reference |
Breast cancer | SXR activators inhibited cell proliferation and induced apoptosis in breast cancer cells. Wild-type p53 was mechanistically required for the anti-proliferative phenotype of PXR. | [37] |