From: Complex roles of filamin-A mediated cytoskeleton network in cancer progression
Research system | Observations | Reference |
---|---|---|
Literatures reported the role of filamin-A in facilitating metastasis and cell locomotion | ||
Meckel-Gruber syndrome patient | Filamin-A interacts with the cytoplasmic domain of meckelin, a transmembrane receptor, which is essential for neuronal migration and Wnt signalling | [111] |
Hepatocellular carcinoma (HCC) | Comparative proteomics revealed that high level of filamin-A expression is associated with increased metastatic potentials of HCC cells. | [112] |
Cancer tissues | By using a newly developed antibody that recognizes secreted variant of filamin-A, gradually increased levels of filamin-A was detected in normal breast tissue, localized and invasive breast cancer, which is associated with cancer progression. | [113] |
Prostate cancer cell and tissue microarray | Filamin-A proteolysis results in nuclear localization of 90 kDa fragment, which is associated with decreased cancer metastasis, while elevated cytoplasmic levels of filamin-A was associated with enhanced metastatic potential | [114] |
FlnA-knockdown rats | Filamin-A deficiency results in the abnormal migration, and then further causes disorganization of radial glia, which is the leading cause of PH pathogenesis. | [115] |
NIH3T3 and HT1080 cells | Interaction of filamin-A with androgen receptor is essential for integrin β1 and FAK activation and cell migration induced by androgen stimulation | [79] |
M2 and A7 melanoma cells | Filamin-A functions to stabilize cortical actin in vivo and is required for efficient cell locomotion | [16] |
FlnA null mouse platelets | The interaction between FlnA and Syk regulates ITAM- and ITAM-like-containing receptor signaling which is essential for platelet spreading | [58] |
M2 melanoma cells | R-Ras regulates migration through an interaction with filamin A in melanoma cells | [57] |
EK-293 cells | Filamin A interacts with vimentin to regulation of cell adhesion to collagen through recycling beta1 integrins to cell membrane | |
Melanoma and breast cancer cells and breast cancer TMA | Filamin-A deficiency in melanoma and breast cancer cells reduces not only cell motility and invasiveness, but also spontaneous and systemic metastasis in nude mouse xenograft. Decreased filamin-A expression levels in cancer cells are associated with better survival of distant metastasis-free in breast cancer patients. | [116] |
Literatures reported the role of filamin-A inhibiting metastasis | ||
Human fibrosarcoma cells | Filamin-A deficiency increases matrix metalloproteinase (MMP) activity and induces MMP2 activation, enhancing the ability of cells to remodel the ECM and increasing their invasive potential | [108] |
HT1080 and Jurkat cells | Filamins play a role in cell migration and spreading through the interactions between filamins and transmembrane or signaling proteins, which is mediated at least in part by repeat 19 to 21. | [117] |
A7 melanoma cells | Migfilin acts as a molecular switch to disconnect filamin from integrin for regulating integrin activation and dynamics of extracellular matrix-actin linkage. | [71] |
Hematopoietic cell | ASB2 may regulate hematopoietic cell differentiation by modulating cell spreading and actin remodeling through targeting of filamins for degradation | |
Chinese hamster ovary cells | Tight filamin binding restricts integrin-dependent cell migration by inhibiting transient membrane protrusion and cell polarization. | [105] |
A7 and M2 cells | Co-expression of CEACAM1-L and filamin A lead to a reduced RalA activation, focal adhesion turnover and cell migration | [69] |
Primary melanoma cell line | Wnt5A activates calpain-1, leading to the cleavage of filamin A, which results in a remodeling of the cytoskeleton and an increase in melanoma cell motility. | [120] |
ErbB2 overexpressed breast cancer cells and Breast TMA | Filamin-A deficiency in ErbB2-breast cancer cells reduces FAK turnover and cell motility. Down-regulation of filamin-A in stromal and base membrane is associated with breast cancer progression and invasive lymph node status | [106] |