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Table 1 A partial list of Filamin-A interacting partners

From: Complex roles of filamin-A mediated cytoskeleton network in cancer progression

Interacting partners Binding sites* Approach** Significance Reference
Cytoskeleton and cell shape maintenance
F-actin ABD, Rod-1 b 3D F-actin networks with unique mechanical and physiological properties [47, 54]
Calmodulin ABD b Regulates F-actin binding in vitro [55]
R-Ras 3 b, c Enhances integrin activation and maintains endothelial barrier [56, 57]
Syk 5 b, c Supports ITAM-mediated receptor signaling in platelet [58]
Vimentin 1-8 c Vimentin phosphorylation, cell surface expression of β1 integrins and cell spreading on collagen [52, 53]
Supervillin 8–10, 20–22 a Cell spreading [59]
Membrane and membrane associated proteins
Dopamine D2 and D3 receptors 19 a, b, c Stabilizes β-arrestins-filamin-A complex [60, 61]
Pro-Prion 10,16–18, 20, 21, 23 b, c Enhances the binding of filamin-A with β1 integrin, and promotes cell spreading and migration in melanoma [62, 63]
GPI bα (CD 42b) 17 b, c Intracellular trafficking and maintains the size of platelets [64, 65]
β Integrins 21 c Adhesion, mechanoprotection and competing binding site with talin to regulate integrin activation [66, 67]
Tissue factor 22-24 a, b Supports cell spreading and migration [68]
CEACAM 1 23–24 a, b Reduces cell migration [69]
Migfilin (FBLP-1) 21 a, b, c Disconnects filamin-A from integrin and promotes talin-integrin binding [48, 7072]
Caveolin-1 22-24 a, b Intracellular trafficking [73, 74]
Intracellular signaling
β-arrestins 22 a, b, c ERK activation and actin cytoskeleton reorganization [75]
Wee1 22-24 b, c Regulates Wee1 expression and promotes G2/M phase progression [42]
K-RAS nd nd Filamin-A deficiency reduces K-RAS oncogenic potentials [76]
NIK nd b Mediates the activation of the IKKα/NF-κB cascade through CD28 signaling [77]
sst2 19-20, 21-24 b, c Negative control on PI3K pathway [78]
Androgen receptor 16-19 a, b, c Required for androgen-induced cell migration [79, 80]
SEK1 22-23 a, b, c Tumor necrosis factor-alpha signaling [81]
TRAF2 15-19 a, b, c Inflammatory signal transduction [82]
Small GTP-binding proteins and their regulators
Rho/Cdc42/RalA 24 c Remodeling of cytoskeleton [83]
ROCK 24 b, c Remodeling of cytoskeleton [84]
FilGAP 23 a, b, c Cell spreading and GAP activation [17, 85]
Trio 23–24 c GEF for RhoG/Rac1 and RhoA and required for ruffling [86]
Nuclear function associated proteins
BRCA1 23-24 a, b, c Facilitates the recruitment of BRAC1 and RAD51 to DNA damage sites and stabilizes the DNA-PK holoenzyme [87]
BRCA2 21-24 a, b, c Required for efficient homologous recombination DNA repair and recovery of G2/M phase arrest [8890]
RefilinB 15-24 a, b Stabilizes perinuclear actin actin networks and regulates nuclear shape [91]
TIF-IA, RPA40 ABD b Suppresses ribosomal RNA gene transcription [92]
TAF1B/mKIAA1093 1-7 a, c Possible role in rRNA production, protein translation and the organization of centromeres [93]
  1. Note:
  2. *: This column indicates the domains involved in the respective interactions. Numbers in this column represent the repeat numbers of filamin-A.
  3. **: The approaches used to demonstrate the interaction including, (a) yeast two-hybrid; (b) in vitro pull-down; (c) co-immunoprecipitation; or (nd), not determined.