Table 1 A partial list of Filamin-A interacting partners

Cytoskeleton and cell shape maintenance

F-actin

ABD, Rod-1

b

3D F-actin networks with unique mechanical and physiological properties

[47, 54]

Calmodulin

ABD

b

Regulates F-actin binding in vitro

[55]

R-Ras

3

b, c

Enhances integrin activation and maintains endothelial barrier

[56, 57]

Syk

5

b, c

Supports ITAM-mediated receptor signaling in platelet

[58]

Vimentin

1-8

c

Vimentin phosphorylation, cell surface expression of β1 integrins and cell spreading on collagen

[52, 53]

Supervillin

8–10, 20–22

a

Cell spreading

[59]

Membrane and membrane associated proteins

Dopamine D2 and D3 receptors

19

a, b, c

Stabilizes β-arrestins-filamin-A complex

[60, 61]

Pro-Prion

10,16–18, 20, 21, 23

b, c

Enhances the binding of filamin-A with β1 integrin, and promotes cell spreading and migration in melanoma

[62, 63]

GPI bα (CD 42b)

17

b, c

Intracellular trafficking and maintains the size of platelets

[64, 65]

β Integrins

21

c

Adhesion, mechanoprotection and competing binding site with talin to regulate integrin activation

[66, 67]

Tissue factor

22-24

a, b

Supports cell spreading and migration

[68]

CEACAM 1

23–24

a, b

Reduces cell migration

[69]

Migfilin (FBLP-1)

21

a, b, c

Disconnects filamin-A from integrin and promotes talin-integrin binding

[48, 70–72]

Caveolin-1

22-24

a, b

Intracellular trafficking

[73, 74]

Intracellular signaling

β-arrestins

22

a, b, c

ERK activation and actin cytoskeleton reorganization

[75]

Wee1

22-24

b, c

Regulates Wee1 expression and promotes G2/M phase progression

[42]

K-RAS

nd

nd

Filamin-A deficiency reduces K-RAS oncogenic potentials

[76]

NIK

nd

b

Mediates the activation of the IKKα/NF-κB cascade through CD28 signaling

[77]

sst2

19-20, 21-24

b, c

Negative control on PI3K pathway

[78]

Androgen receptor

16-19

a, b, c

Required for androgen-induced cell migration

[79, 80]

SEK1

22-23

a, b, c

Tumor necrosis factor-alpha signaling

[81]

TRAF2

15-19

a, b, c

Inflammatory signal transduction

[82]

Small GTP-binding proteins and their regulators

Rho/Cdc42/RalA

24

c

Remodeling of cytoskeleton

[83]

ROCK

24

b, c

Remodeling of cytoskeleton

[84]

FilGAP

23

a, b, c

Cell spreading and GAP activation

[17, 85]

Trio

23–24

c

GEF for RhoG/Rac1 and RhoA and required for ruffling

[86]

Nuclear function associated proteins

BRCA1

23-24

a, b, c

Facilitates the recruitment of BRAC1 and RAD51 to DNA damage sites and stabilizes the DNA-PK holoenzyme

[87]

BRCA2

21-24

a, b, c

Required for efficient homologous recombination DNA repair and recovery of G2/M phase arrest

[88–90]

RefilinB

15-24

a, b

Stabilizes perinuclear actin actin networks and regulates nuclear shape

[91]

TIF-IA, RPA40

ABD

b

Suppresses ribosomal RNA gene transcription

[92]

TAF1B/mKIAA1093

1-7

a, c

Possible role in rRNA production, protein translation and the organization of centromeres

[93]