Figure 1
From: Resveratrol induces insulin gene expression in mouse pancreatic α-cells
Resveratrol increase insulin mRNA levels in α-cells via SirT1. (A) qPCR analysis of Ins2 and Gcg mRNA levels after resveratrol treatment (25 μM / 24 hr) with or without SirT1 KD in α-cells. (B) Immunoblot showing efficiency of SirT1 knockdown in α-cells. (C, D) qPCR analysis of endocrine progenitor and β-cell specific markers after resveratrol treatment (25 μM / 24 hr). Bars represent the mean of the respective individual ratios ± SEM (n = 3). (D) qPCR analysis of Pdx1 and Ngn3 mRNA levels after resveratrol treatment (25 μM / 24 hr) with or without SirT1 KD in α-cells. The asterisk indicates P < 0.05.