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Figure 2 | Cell & Bioscience

Figure 2

From: Bone marrow-derived stem cells ameliorate hepatic fibrosis by down-regulating interleukin-17

Figure 2

Liver injury induced by CCl 4 administration. The mice were repeatedly treated with oil alone or CCl4 mixture for 6 weeks to induce liver injury, and then stopped injection to observe spontaneous recovery for 4 weeks. (A) Liver inflammatory (upper panels arrowhead) and hepatic collagen deposition (lower panels arrowhead) were determined by H&E and Sirius red staining. Original magnifications: upper panels × 100, lower panels × 40. (B) The percentage of stained red area of Sirius red was assessed at 100 × magnification with a quantitative image analyzer. (C) Serum chemistry of liver function was performed for albumin (ALB). The expressions of alpha- smooth muscle actin (SMA) (D) and collagen-1 (E) mRNA in liver tissues were measured by real time (RT)-PCR. CCl4 6w, 6-week CCl4 injection; Rec 4w, stopped CCl4 injection for 4-week to recover spontaneously. *p < 0.05, **p < 0.01.

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