Sorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients

Table 2 Summary of the SNPs associated with the CAA formation in Taiwanese Kawasaki disease

SNP	Chromosome	Cytoband	Physical position	Nearest genes		CAA-	CAA+
						No. (%)	No. (%)	p value	Odds ratio (95% CI)
rs154507	5	q23.2	122228806	SNX24	GG	24 (12.9)	14 (18.4)	0.234	1.94 (0.86–4.41)
					GC	92 (49.5)	41 (54.0)		1.49 (0.81–2.74)
					CC	70 (37.6)	21 (27.6)		1
rs27740	5	q23.2	122232671	SNX24	TT	24 (12.9)	14 (18.4)	0.234	1.94 (0.86–4.41)
					TA	92 (49.5)	41 (54.0)		1.49 (0.81–2.74)
					AA	70 (37.6)	21 (27.6)		1
rs26371	5	q23.2	122234424	SNX24	TT	44 (23.7)	12 (15.8)	0.123	0.45 (0.20–1.01)
					TC	99 (53.2)	38 (50.0)		0.63 (0.34–1.17)
					CC	43 (23.1)	26 (34.2)		1
rs6595415	5	q23.2	122234657	SNX24	TT	23 (12.4)	15 (19.7)	0.198	2.07 (0.93–4.61)
					TC	90 (48.4)	38 (50.0)		1.34 (0.73–2.45)
					CC	73 (39.2)	23 (30.3)		1
rs17149732	5	q23.2	122249811	SNX24	TT	23 (12.4)	14 (18.4)	0.261	1.93 (0.86–4.36)
					TG	90 (48.4)	39 (51.3)		1.38 (0.75–2.51)
					GG	73 (39.2)	23 (30.3)		1
rs17149748	5	q23.2	122295266	SNX24	CC	23 (12.4)	14 (18.4)	0.242	1.96 (0.87–4.45)
					CT	91 (49.2)	40 (52.6)		1.42 (0.77–2.60)
					TT	71 (38.4)	22 (29.0)		1
rs1038078	5	q23.2	122309550	SNX24	AA	23 (12.4)	14 (18.4)	0.283	1.91 (0.84–4.30)
					AG	91 (48.9)	39 (51.3)		1.34 (0.74–2.45)
					GG	72 (38.7)	23 (30.3)		1
rs28891	5	q23.2	122311523	SNX24	CC	39 (21.0)	8 (10.6)	*0.006*	0.29 (0.12–0.70)
					CT	99 (53.2)	34 (44.7)		0.48 (0.27–0.87)
					TT	48 (25.8)	34 (44.7)		1
rs6595423	5	q23.2	122341433	SNX24	CC	23 (12.4)	13 (17.1)	0.322	1.79 (0.79–4.10)
					CT	90 (48.4)	40 (52.6)		1.41 (0.78–2.57)
					TT	73 (39.2)	23 (30.3)		1

SNX24, sorting nexin 24; SNP, single nucleotide polymorphism; CAA, Coronary artery aneurysm; CI, confidence interval.
p-values were obtained by chi-square test.
Bold, emphasizing statistical significance was considered as p value <0.05.