Sorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients

Table 1 Genotype distributions of SNX24 gene SNPs in Taiwanese KD patients and controls

SNP	Chromosome	Cytoband	Physical position	Nearest genes		Controls	KD patients
						No. (%)	No. (%)	p value	Odds ratio (95% CI)
rs154507	5	q23.2	122228806	SNX24	GG	146 (13.2)	38 (14.5)	0.755	1.17 (0.76–1.78)
					GC	553 (50.0)	133 (50.8)		1.08 (0.80–1.45)
					CC	408 (36.8)	91 (34.7)		1
rs27740	5	q23.2	122232671	SNX24	TT	156 (14.1)	38 (14.5)	0.867	1.08 (0.71–1.65)
					TA	547 (49.4)	133 (50.8)		1.08 (0.80–1.45)
					AA	404 (36.5)	91 (34.7)		1
rs26371	5	q23.2	122234424	SNX24	TT	217 (19.6)	56 (21.4)	0.690	1.19 (0.80–1.76)
					TC	573 (51.8)	137 (52.3)		1.10 (0.80–1.51)
					CC	317 (28.7)	69 (26.3)		1
rs6595415	5	q23.2	122234657	SNX24	TT	151 (13.6)	38 (14.5)	0.842	1.12 (0.73–1.70)
					TC	530 (47.9)	128 (48.9)		1.07 (0.80–1.44)
					CC	426 (38.5)	96 (36.6)		1
rs17149732	5	q23.2	122249811	SNX24	TT	146 (13.2)	37 (14.1)	0.784	1.14 (0.74–1.73)
					TG	530 (47.9)	129 (49.2)		1.09 (0.81–1.46)
					GG	430 (38.9)	96 (36.6)		1
rs17149748	5	q23.2	122295266	SNX24	CC	150 (13.6)	37 (14.1)	0.710	1.13 (0.74–1.72)
					CT	532 (48.1)	131 (50.0)		1.13 (0.84–1.51)
					TT	425 (38.4)	93 (35.5)		1
rs1038078	5	q23.2	122309550	SNX24	AA	147 (13.3)	37 (14.1)	0.676	1.15 (0.75–1.76)
					AG	526 (47.5)	130 (49.6)		1.13 (0.84–1.51)
					GG	434 (39.2)	95 (36.3)		1
rs28891	5	q23.2	122311523	SNX24	CC	187 (16.9)	47 (17.9)	0.836	1.12 (0.75–1.67)
					CT	554 (50.1)	133 (50.8)		1.07 (0.79–1.45)
					TT	366 (33.1)	82 (31.3)		1
rs6595423	5	q23.2	122341433	SNX24	CC	144 (13.0)	36 (13.7)	0.667	1.14 (0.75–1.75)
					CT	524 (47.3)	130 (49.6)		1.13 (0.85–1.52)
					TT	439 (39.7)	96 (36.6)		1

SNX24, sorting nexin 24; SNP, single nucleotide polymorphism; CI, confidence interval.
p-values were obtained by chi-square test.
Bold, emphasizing statistical significance was considered as p value <0.006 (0.05/9).

ISSN: 2045-3701