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Figure 2 | Cell & Bioscience

Figure 2

From: Enhancing myogenic differentiation of pluripotent stem cells with small molecule inducers

Figure 2

Schematic presentation of the molecular mechanisms of myogenic differentiation. RA directs myogenic differentiation through the regulation of Pax3 and Myf5 gene expression, whereas bexarotene (BEX) enhances the commitment of skeletal muscle lineage through the Meox1 and Pax3 pathways. The histone acetyltransferase p300 is directly involved in the regulation of myogenic differentiation through histone acetylation at the Pax3, Myf5, and MyoD gene loci. Solid arrows indicate identified regulatory pathways, whereas a dashed arrow suggests a potential regulatory pathway.

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