Figure 1From: Enhancing myogenic differentiation of pluripotent stem cells with small molecule inducersSchematic diagrams of the bimodal function of the nuclear receptors. In the absence of RA, the DNA-bound RAR-RXR heterodimer associates with the NCoR corepressor complex to repress gene transcription. Following RA induction, the RAR-RXR heterodimer recruits the p300 coactivator complex to initiate gene activation through chromatin remodeling and the release of RNA Pol II.Back to article page