Table 3 Summary of known direct downstream events/substrates of LATS/NDR kinases
From: Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling
Kinase(s) | Substrate | Role of phosphorylation |
|---|---|---|
LATS1/2 | YAP on Ser61 | |
LATS1/2 | YAP on Ser109 | |
LATS1/2 | YAP on Ser127 | |
LATS1/2 | YAP on Ser164 | |
LATS1/2 | YAP on Ser381 | Regulation of YAP protein stability[95] |
LATS1/2 | TAZ on Ser66 | Not specifically determined[93] |
LATS1/2 | TAZ on Ser89 | Facilitates 14-3-3 binding/cytoplasmic retention[93, 96, 97] |
LATS1/2 | TAZ on Ser117 | Not specifically determined[93] |
LATS1/2 | TAZ on Ser311 | Regulation of TAZ protein stability[98] |
LATS1 | MYPT1 on Ser445 | Promotes MYPT1 phosphatase activity[99] |
LATS2 | 14-3-3γ on Ser59 | Regulation of 14-3-3γ in P-body formation[55] |
LATS2 | Snail on Thr203 | Regulating of Snail1 protein stability[100] |
NDR1/2 | p21/Cip1 on Ser146 | Regulates p21 protein stability[45] |
NDR1/2 | AAK1 on Ser635 | Dendrite and spine development in neurons[101] |
NDR1/2 | Rabin8 on Ser240# | Dendrite and spine development in neurons[101] |
NDR2 | Rabin8 on Ser272# | Primary cilia biology[102] |
NDR1/2 | PI4KB on Ser277* | Not determined[101] |
NDR1/2 | Panx2 on Ser514* | Not determined[101] |
NDR1/2 | Rab11fip5 on Ser307* | Not determined[101] |