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Table 3 Summary of known direct downstream events/substrates of LATS/NDR kinases

From: Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling

Kinase(s) Substrate Role of phosphorylation
LATS1/2 YAP on Ser61 Not specifically determined[29, 92]
LATS1/2 YAP on Ser109 Not specifically determined[29, 92]
LATS1/2 YAP on Ser127 Facilitates 14-3-3 binding/cytoplasmic retention[9, 29, 94]
LATS1/2 YAP on Ser164 Not specifically determined[29, 92]
LATS1/2 YAP on Ser381 Regulation of YAP protein stability[95]
LATS1/2 TAZ on Ser66 Not specifically determined[93]
LATS1/2 TAZ on Ser89 Facilitates 14-3-3 binding/cytoplasmic retention[93, 96, 97]
LATS1/2 TAZ on Ser117 Not specifically determined[93]
LATS1/2 TAZ on Ser311 Regulation of TAZ protein stability[98]
LATS1 MYPT1 on Ser445 Promotes MYPT1 phosphatase activity[99]
LATS2 14-3-3γ on Ser59 Regulation of 14-3-3γ in P-body formation[55]
LATS2 Snail on Thr203 Regulating of Snail1 protein stability[100]
NDR1/2 p21/Cip1 on Ser146 Regulates p21 protein stability[45]
NDR1/2 AAK1 on Ser635 Dendrite and spine development in neurons[101]
NDR1/2 Rabin8 on Ser240# Dendrite and spine development in neurons[101]
NDR2 Rabin8 on Ser272# Primary cilia biology[102]
NDR1/2 PI4KB on Ser277* Not determined[101]
NDR1/2 Panx2 on Ser514* Not determined[101]
NDR1/2 Rab11fip5 on Ser307* Not determined[101]
  1. #NDR kinases can phosphorylate the same conserved motif in mouse and human Rabin8.
  2. *Potential substrates that have yet to be confirmed as direct substrates.