Table 2 Summary of reported targeting motifs of LATS/NDR substrates
From: Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling
Targeting motif | Kinase(s) | Target site |
|---|---|---|
HVRGDpS | LATS1/2 | |
HSRQApS | LATS1/2 | |
HVRAHpS | LATS1/2 | |
HLRQSpS | LATS1/2 | |
HSRDEpS | LATS1/2 | |
HSRQSpS | LATS1/2 | TAZ on Ser66[93] |
HVRSHpS | LATS1/2 | TAZ on Ser89[93] |
HLRQQpS | LATS1/2 | TAZ on Ser117[93] |
HSREQpS | LATS1/2 | TAZ on Ser311[93] |
LRKTGpS | LATS1 | MYPT1 on Ser445[99] |
GARRSpS | LATS2 | 14-3-3γ on Ser59[55] |
HVRTHpT | LATS2 | Snail1 on Thr203[100] |
KRRQTpS | NDR1/2 | p21 on Ser146[45] |
HRRILpS | NDR1/2 | AAK1 on Ser635[101] |
HTRNKpS | NDR/2 | Rabin8(mouse) on Ser240[101] |
HTRNKpS | NDR2 | Rabin8(human) on Ser272[102] |
H XR XXpS/T | Â | Â |