Skip to main content

Table 1 Overview of the regulation of mammalian LATS/NDR kinases by phosphorylation

From: Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling

Kinase(s)

Upstream kinase

Site(s)

Role of phosphorylation

NDR1/2

Auto-phosphorylation

Ser281/Ser282

Essential for kinase activity[38, 41, 47]

NDR1/2

MST1/2

Thr444/Thr442

Crucial for kinase activity[38, 41, 43, 44]

NDR1/2

MST3

Thr442

Crucial for kinase activity[45, 46]

LATS1

Unknown mechanism#

Ser909

Essential for kinase activity[48, 49]#

LATS1

MST1/2#

Thr1079

Essential for kinase activity[48, 49]#

LATS1

Cdk1/cyclin B

Thr490

Might play a role in mitosis[50]

  

Ser613

 

LATS1

NUAK1

Ser464

Controls LATS1 protein stability[51]

LATS2

Aurora A

Ser83/Ser380

plays a role in mitosis[52–54]

LATS2

CHK1/2

Ser408

Plays a role in DNA damage signalling[55]

LATS2

PKA

Ser172

Regulate LATS2 activity towards YAP[56]

  

Ser380

 
  

Ser592

 
  

Ser598

 
  1. #The potential auto- and trans-phosphorylation events on LATS1/2 (on Ser909/Ser872 and Thr1079/Thr1041) are not yet dissected. Therefore, we can only predict here that MST1/2 mainly phosphorylate Thr1079/Thr1041 on LATS1/2, based on the reported conserved regulatory mechanism between MST1/2 and NDR1/2 in human cells[43, 44] and Hippo and Warts/Trc in fly cells[57].