From: Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling
Kinase(s) | Upstream kinase | Site(s) | Role of phosphorylation |
---|---|---|---|
NDR1/2 | Auto-phosphorylation | Ser281/Ser282 | |
NDR1/2 | MST1/2 | Thr444/Thr442 | |
NDR1/2 | MST3 | Thr442 | |
LATS1 | Unknown mechanism# | Ser909 | |
LATS1 | MST1/2# | Thr1079 | |
LATS1 | Cdk1/cyclin B | Thr490 | Might play a role in mitosis[50] |
 |  | Ser613 |  |
LATS1 | NUAK1 | Ser464 | Controls LATS1 protein stability[51] |
LATS2 | Aurora A | Ser83/Ser380 | |
LATS2 | CHK1/2 | Ser408 | Plays a role in DNA damage signalling[55] |
LATS2 | PKA | Ser172 | Regulate LATS2 activity towards YAP[56] |
 |  | Ser380 |  |
 |  | Ser592 |  |
 |  | Ser598 |  |