Table 1 Phenotypes of the Mst1/2 conditional knockout mice

Dramatic hepatocyte proliferation and hepatomegaly; Development of hepatocellular carcinoma (HCC) and cholangiocarcinoma within 2 months.

Intestinal dysplasia; An expansion of stem-like undifferentiated cells; An almost complete absence of all secretory lineages; Development of the polypoid lesions and colonic adenomas within 3 months old.

A significantly decrease in pancreas mass; Acinar cell atrophy; Overabundance of ductal structures; Smaller islets with abnormal α/β cell ratios in pancreas

Expansion of trabecular and subcompact ventricular myocardial layers; Thickened ventricular walls, and enlarged ventricular chambers without a change in myocardial cell size.