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Table 1 Phenotypes of the Mst1/2 conditional knockout mice

From: Mst1 and Mst2 kinases: regulations and diseases

Affected tissue Phenotypes of Mst1/2 deficient mice References
Liver Dramatic hepatocyte proliferation and hepatomegaly; Development of hepatocellular carcinoma (HCC) and cholangiocarcinoma within 2 months. 46,49,50
Intestines Intestinal dysplasia; An expansion of stem-like undifferentiated cells; An almost complete absence of all secretory lineages; Development of the polypoid lesions and colonic adenomas within 3 months old. 52
Pancreas A significantly decrease in pancreas mass; Acinar cell atrophy; Overabundance of ductal structures; Smaller islets with abnormal α/β cell ratios in pancreas 59,60
Heart Expansion of trabecular and subcompact ventricular myocardial layers; Thickened ventricular walls, and enlarged ventricular chambers without a change in myocardial cell size. 66