Figure 8
From: Multiscale mechanobiology: mechanics at the molecular, cellular, and tissue levels
Epithelium-mesenchyme interaction in skin appendage patterning. a, The schematics of the epithelial placode formation and the mesenchymal condensation. b, The progressive formation of feather buds at chicken embryo. c, A homogeneous treatment of FGF4 enlarges feather primodia. d, A localized treatment of FGF4 leads to a local enlargement of feather primodia. Scale bar in b, d: 5 mm. b-d are adapted from Ref. [61].