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Figure 1 | Cell & Bioscience

Figure 1

From: Working hard for recovery: mitotic kinases in the DNA damage checkpoint

Figure 1

A multi-brake model of the G2/M DNA damage checkpoint. Activation of the DNA damage checkpoint and maintenance of cell cycle arrest require not only inhibition of Cdk1, but also independent targeting of Plk1, Aurora A and Gwl. Detailed mechanisms through which the DNA damage checkpoint suppresses Plk1, Aurora A and Gwl kinases remain to be clarified (as denoted by the question mark).

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