Figure 1
From: Working hard for recovery: mitotic kinases in the DNA damage checkpoint
A multi-brake model of the G2/M DNA damage checkpoint. Activation of the DNA damage checkpoint and maintenance of cell cycle arrest require not only inhibition of Cdk1, but also independent targeting of Plk1, Aurora A and Gwl. Detailed mechanisms through which the DNA damage checkpoint suppresses Plk1, Aurora A and Gwl kinases remain to be clarified (as denoted by the question mark).