Figure 3
From: Regulation of germ layer formation by pluripotency factors during embryogenesis
A model for the function of Klf4 during Xenopus germ layer formation. Klf4 induces endoderm differentiation via activation of Nodal pathway or directly via activation of endoderm inducing genes, which repress mesodermal gene expression. Klf4 also promotes dorsalization of body axis via stimulation of a subset of genes in the Spemann organizer. When Klf4 activity is blocked, germ layer formation and body axis patterning are also inhibited.