Figure 2

Targeting GSK3β results in neuroprotection from IR-induced neurotoxicity. Model depicting potential targeting of GSK3β-NHEJ signaling pathway to decrease neurotoxicity and increase the therapeutic index of anti-glioma treatment. Inhibition of GSK3β results in the upregulation of DNA-PK dependent NHEJ repair in neural but not tumor cells. By targeting GSK3β, neurons, but not GBM cells, gain enhanced DNA repair functionality, and therefore protected from IR-induced neuronal cell death.