Figure 5

TGF-β receptors can function independent of downstream signaling molecules Smads, MAPKs or Akt. (A) TβRII can interact with Par6 to induce degradation of RhoA, leading to epithelia-mesenchymal transition. (B) The intracellular domain (ICD) of TβRI can be cleaved by TACE and translocate into the nucleus to regulate transcription associated with p300.