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Figure 5 | Cell & Bioscience

Figure 5

From: Regulation of TGF-β receptor activity

Figure 5

TGF-β receptors can function independent of downstream signaling molecules Smads, MAPKs or Akt. (A) TβRII can interact with Par6 to induce degradation of RhoA, leading to epithelia-mesenchymal transition. (B) The intracellular domain (ICD) of TβRI can be cleaved by TACE and translocate into the nucleus to regulate transcription associated with p300.

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