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Table 9 Top networks affected by up-regulated genes/isoforms in rheumatoid arthritis synovial RNA

From: RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis

  Up-regulated genes
Top Functions Score Genes
Inflammatory Response, Immunological Disease, Cell Death 68 58
Cell Morphology, Tissue Development, Cell Death 30 36
Cell-To-Cell Signaling and Interaction, Hematological System   
Development and Function, Immune Cell Trafficking 25 32
Inflammatory Response, Infectious Disease, Immunological Disease 23 31
Cellular Development, Cancer, Developmental Disorder 22 30
Inflammatory Response, Cellular Development, Cell Death 22 30
Cell Death, Hematological System Development and Function, Tissue Morphology 22 30
  Up-Regulated Isoforms
Top Functions Score Genes
Inflammatory Response, Cellular Movement, Cell-To-Cell Signaling and Interaction 88 70
Cellular Development, Cell Death, Cellular Growth and Proliferation 26 36
Inflammatory Response, Organismal Injury and Abnormalities, Cellular Movement 24 35
Cellular Growth and Proliferation, Cellular Development, Cancer 24 35
Cell-To-Cell Signaling and Interaction, Inflammatory Response, Hematological System Development and Function 23 34
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking 23 34
  1. Networks significantly affected in RASFs compared to control SFs as determined by Ingenuity Pathway Analysis. The score is based on the p-value of the affected network. Networks with a score of 15 or greater were defined as significant.