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Table 9 Top networks affected by up-regulated genes/isoforms in rheumatoid arthritis synovial RNA

From: RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis

 

Up-regulated genes

Top Functions

Score

Genes

Inflammatory Response, Immunological Disease, Cell Death

68

58

Cell Morphology, Tissue Development, Cell Death

30

36

Cell-To-Cell Signaling and Interaction, Hematological System

  

Development and Function, Immune Cell Trafficking

25

32

Inflammatory Response, Infectious Disease, Immunological Disease

23

31

Cellular Development, Cancer, Developmental Disorder

22

30

Inflammatory Response, Cellular Development, Cell Death

22

30

Cell Death, Hematological System Development and Function, Tissue Morphology

22

30

 

Up-Regulated Isoforms

Top Functions

Score

Genes

Inflammatory Response, Cellular Movement, Cell-To-Cell Signaling and Interaction

88

70

Cellular Development, Cell Death, Cellular Growth and Proliferation

26

36

Inflammatory Response, Organismal Injury and Abnormalities, Cellular Movement

24

35

Cellular Growth and Proliferation, Cellular Development, Cancer

24

35

Cell-To-Cell Signaling and Interaction, Inflammatory Response, Hematological System Development and Function

23

34

Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking

23

34

  1. Networks significantly affected in RASFs compared to control SFs as determined by Ingenuity Pathway Analysis. The score is based on the p-value of the affected network. Networks with a score of 15 or greater were defined as significant.