Table 8 Top ten up- and down- regulated novel isoforms expressed in rheumatoid arthritis synovial RNA

FBN1

fibrillin 1

chr15:48700502-48944261

3642

0.35665

122.625

343.82

ENSG00000166147

TNXB

tenascin XB

chr6:31913771-32077409

10005

0.0711364

9.52612

133.91

ENSG00000168477

VCAN

versican

chr5:82767225-82878111

7388

0.145287

17.706

121.87

ENSG00000038427

LRP1

low density lipoprotein receptor-related protein 1

chr12:57522228-57607140

6609

0.223758

19.9154

89.00

ENSG00000123384

DPYSL2

dihydropyrimidinase-like 2

chr8:26435420-26515693

3416

0.287829

23.9348

83.16

ENSG00000092964

-

Genes nearby:FAM198B: family with sequence similarity 198, member B

chr4:159045731-159093718

1964

0.064901

5.20752

80.24

ENSG00000164125

-

Genes nearby:TGFBR3: transforming growth factor, beta receptor III

chr1:92145899-92351836

1323

0.137404

11.0015

80.07

ENSG00000069702

ALDH1L2

aldehyde dehydrogenase 1 family, member L2

chr12:105413561-105478341

4568

0.0522639

3.45172

66.04

ENSG00000136010

-

NA

chr14:74964883-75079368

2880

0.114262

6.82866

59.76

NA

Genes nearby: ISCA2: iron-sulfur cluster assembly 2 homolog

ENSG00000165898

SNED1

LTBP2: latent transforming growth factor beta binding protein 2

chr2:241936998-242041710

8107

0.15755

9.34599

59.32

ENSG00000119681

TINAGL1

tubulointerstitial nephritis antigen-like 1

chr1:32041807-32053290

995

129.883

0.462813

−280.64

ENSG00000142910

TPM2

tropomyosin 2 (beta)

chr9:35681989-35690053

1083

78.6638

0.329924

−238.43

ENSG00000198467

MT2A

metallothionein 2A

chr16:56642376-56692994

248

701.232

5.35657

−130.91

ENSG00000125148

FSTL1

follistatin-like 1

chr3:120113060-120169918

1640

10.7318

0.0822263

−130.52

ENSG00000163430

ITPRIP

inositol 1,4,5-trisphosphate receptor interacting protein

chr10:106069730-106098576

6523

18.5495

0.146115

−126.95

ENSG00000148841

-

NA

chr13:41958154-41958844

690

51.6499

0.522452

−98.86

NA

SPTBN1

spectrin, beta, non-erythrocytic 1

chr2:54683453-54898583

7086

12.396

0.126624

−97.90

ENSG00000115306

HLA-DRB1

major histocompatibility complex, class II, DR beta 5

chr6:32441211-32557589

513

12.6351

0.129095

−97.87

ENSG00000198502

SEMA3F

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

chr3:50192454-50226507

3394

6.92733

0.0764133

−90.66

ENSG00000001617

CNN1

calponin 1, basic, smooth muscle

chr19:11649578-11661139

659

67.4653

0.799449

−84.39

ENSG00000130176