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Table 7 Top ten up- and down- regulated novel isoforms expressed only in normal synovial RNA or rheumatoid arthritis synovial RNA

From: RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis

Gene

Description

Coordinates

Length

FPKM Wildtype

FPKM RA

Ensembl gene ID

GIPC1

GIPC PDZ domain containing family. Member 1

chr19:14588570-14606944

1650

--

8.09135

ENSG00000123159

MPPE1

Metallophosphoesterase 1

chr18:11883385-11908455

1973

--

5.66007

ENSG00000154889

-

NA

chr11:69066649-69184402

410

--

5.19725

NA

EPB41L2

Erythrocyte membrane protein band 4.1-like 2

chr6:131160487-131384462

3393

--

4.45046

ENSG00000079819

MRPL14

Mitochondrial ribosomal protein L14

chr6:44072507-44123256

658

--

4.29538

ENSG00000180992

PPIEL

Peptidylprolyl isomerase E-like pseudogene

chr1:39987953-40025316

509

--

4.21536

ENSG00000243970

-

NA

chr6:166822859-167041186

3525

--

3.83632

NA

-

NA

chr21:39607975-39679370

1369

--

3.3631

NA

FAM101A

Family with sequence similarity 101. member A

chr12:124774147-124800566

2242

--

3.16322

ENSG00000178882

-

NA

chr4:39454172-39460535

666

--

3.12642

NA

-

NA

chr20:30432079-30433458

1379

18.1953

--

NA

GPAT2

Glycerol-3-phosphate acyltransferase 2, mitochondrial

chr2:96687342-96700658

2732

6.12103

--

ENSG00000186281

PCDHGC5

Protocadherin gamma subfamily C, 5

chr5:140746308-140914003

4930

6.08509

--

ENSG00000240764

RSAD2

Radical S-adenosyl methionine domain containing 2

chr2:6988770-7038095

5210

4.87066

--

ENSG00000134321

HEYL

Hairy/enhancer of split related with YRPW motif-like

chr1:40089102-40105348

3872

4.34476

--

ENSG00000163909

GPR107

G protein-coupled receptor 107

chr9:132815745-132902440

3463

4.15184

--

ENSG00000148358

GOLGA2

Golgin A2

chr9:131018105-131038268

3014

2.8846

--

ENSG00000167110

HHIP

Hedgehog interacting protein

chr4:145567142-145660251

2628

2.57248

--

ENSG00000164161

ITIH3

Inter-alpha-trypsin inhibitor heavy chain 3

chr3:52828743-52838029

1944

2.20862

--

ENSG00000162267

HEATR5A

HEAT repeat containing 5A

chr14:31757730-31889797

6427

2.17675

--

ENSG00000129493

  1. Novel isoforms which were differentially expressed as determined by CuffDiff after Benjamini-Hochberg correction. The isoforms were ranked by FPKM and the 10 with the highest or lowest fold changes are listed here.