Table 6 Top ten up- and down- regulated known isoforms expressed in rheumatoid arthritis synovial RNA
From: RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis
Gene | Description | Locus | Length | RA1FPKM | RA2FPKM | WT1FPKM | WT2FPKM | Avg.RA | Avg.WT | Fold change | Ensembl geneID |
|---|---|---|---|---|---|---|---|---|---|---|---|
IL26 | interleukin 26 | chr12 | 1047.00 | 17.91 | 1.93 | 0.10 | 0.14 | 9.92 | 0.12 | 80.83 | ENSG00000111536 |
GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | chr9 | 5478.00 | 3.99 | 3.35 | 0.08 | 0.05 | 3.67 | 0.07 | 55.82 | ENSG00000187210 |
IFI27 | interferon, alpha-inducible protein 27 | chr14 | 652.00 | 272.04 | 223.93 | 5.09 | 8.77 | 247.99 | 6.93 | 35.79 | ENSG00000165949 |
GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | chr9 | 5596.00 | 3.81 | 2.20 | 0.06 | 0.13 | 3.01 | 0.09 | 32.54 | ENSG00000187210 |
IGFBP3 | insulin-like growth factor binding protein 3 | chr7 | 2631.00 | 123.09 | 213.34 | 2.30 | 8.88 | 168.22 | 5.59 | 30.09 | ENSG00000146674 |
DHPS | deoxyhypusine synthase | chr19 | 1184.00 | 12.04 | 2.92 | 0.40 | 0.14 | 7.48 | 0.27 | 27.42 | ENSG00000095059 |
BLCAP | bladder cancer associated protein | chr20 | 2073.00 | 9.25 | 2.16 | 0.20 | 0.32 | 5.70 | 0.26 | 22.14 | ENSG00000166619 |
SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | chr1 | 2438.00 | 62.93 | 20.78 | 0.21 | 3.63 | 41.85 | 1.92 | 21.79 | ENSG00000142583 |
SLC12A8 | solute carrier family 12 (potassium/chloride transporters), member 8 | chr3 | 3447.00 | 6.34 | 16.64 | 0.32 | 0.73 | 11.49 | 0.52 | 22.01 | ENSG00000221955 |
LYNX1 | Ly6/neurotoxin 1 | chr8 | 1290.00 | 6.07 | 3.23 | 0.39 | 0.06 | 4.65 | 0.23 | 20.48 | ENSG00000180155 |
C5orf13 | chromosome 5 open reading frame 13 | chr5 | 1996.00 | 0.32 | 0.71 | 303.46 | 6.35 | 0.52 | 154.91 | −300.00 | ENSG00000134986 |
IFI27 | interferon, alpha-inducible protein 27 | chr14 | 648.00 | 0.40 | 1.10 | 5.62 | 318.85 | 0.75 | 162.23 | −216.80 | ENSG00000165949 |
C5orf13 | chromosome 5 open reading frame 13 | chr5 | 2068.00 | 0.14 | 0.19 | 40.42 | 1.50 | 0.16 | 20.96 | −127.90 | ENSG00000134986 |
APLP2 | amyloid beta (A4) precursor-like protein 2 | chr11 | 3274.00 | 0.06 | 0.23 | 5.27 | 15.27 | 0.14 | 10.27 | −71.07 | ENSG00000084234 |
CSRP1 | cysteine and glycine-rich protein 1 | chr1 | 1938.00 | 0.20 | 0.41 | 34.33 | 3.74 | 0.31 | 19.03 | −61.54 | ENSG00000159176 |
AQP1 | aquaporin 1 | chr7 | 2807.00 | 4.71 | 2.55 | 390.29 | 23.23 | 3.63 | 206.76 | −56.95 | ENSG00000240583 |
PARP2 | poly (ADP-ribose) polymerase 2 | chr14 | 1887.00 | 0.10 | 0.19 | 2.43 | 6.85 | 0.14 | 4.64 | −32.85 | ENSG00000129484 |
APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | chr22 | 1536.00 | 0.08 | 0.26 | 2.60 | 7.41 | 0.17 | 5.00 | −29.50 | ENSG00000179750 |
CCDC3 | coiled-coil domain containing 3 | chr10 | 2738.00 | 0.12 | 0.10 | 4.49 | 1.71 | 0.11 | 3.10 | −27.21 | ENSG00000151468 |
MTIF3 | mitochondrial translational initiation factor 3 | chr13 | 1098.00 | 0.14 | 0.22 | 3.98 | 5.73 | 0.18 | 4.85 | −26.92 | ENSG00000122033 |