Skip to main content

Advertisement

Table 4 Top ten up- and down- regulated genes expressed in rheumatoid arthritis synovial RNA

From: RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis

Gene Description Chr RAFPKM RA2FPKM WT2FPKM WT2FPKM Avg.RA Avg.WT Foldchange Ensembl gene ID
IL26 interleukin 26 solute carrier family 2 (facilitated chr12 17.913 1.927 0.101 0.144 9.920 0.123 80.83 ENSG00000111536
SLC2A5 glucose/fructose transporter), member 5 chr1 65.268 21.844 0.340 3.851 43.556 2.096 20.79 ENSG00000142583
PLXDC2 plexin domain containing 2 v-maf musculoaponeurotic chr10 9.222 2.316 0.098 0.573 5.769 0.335 17.21 ENSG00000120594
MAFB fibrosarcoma oncogene homolog B (avian) solute carrier family 14 (urea chr20 37.177 6.679 0.605 2.096 21.928 1.351 16.24 ENSG00000204103
SLC14A1 transporter), member 1 (Kidd blood group chr18 6.188 2.096 0.360 0.177 4.142 0.269 15.41 ENSG00000141469
ADRA2A adrenergic, alpha-2A-, receptor chr10 4.373 10.666 0.899 0.145 7.519 0.522 14.42 ENSG00000150594
MAN1C1 mannosidase, alpha, class 1C, member 1 chr1 16.774 24.3346 0.65654 2.7991 20.554 1.728 11.90 ENSG00000117643
CFI complement factor I solute carrier family 12 chr4 21.803 28.7589 0.10437 4.3263 25.281 2.215 11.41 ENSG00000205403
SLC12A8 (potassium/chloride transporters), member 8 chr3 7.442 15.2539 0.62851 1.4395 11.348 1.034 10.97 ENSG00000221955
THBS4 thrombospondin 4 chr5 5.8622 7.09226 0.05843 1.2202 6.477 0.639 10.13 ENSG00000113296
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 chr18 0.236 0.095 16.207 10.030 0.166 13.118 −79.11 ENSG00000197632
AQP1 aquaporin 1 (Colton blood group) chr7 5.675 3.860 396.183 25.802 4.768 210.992 −44.26 ENSG00000240583
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B chr22 0.0775 0.23398 2.59902 7.4102 0.156 5.005 −32.13 ENSG00000179750
NEFM neurofilament, medium polypeptide chr8 0.0592 0.07122 3.69528 0.2014 0.065 1.948 −29.87 ENSG00000104722
CCDC3 coiled-coil domain containing 3 chr10 0.1241 0.09255 4.48673 1.7074 0.108 3.097 −28.59 ENSG00000151468
F10 coagulation factor X chr13 0.197 0.21727 8.44739 2.9581 0.207 5.703 −27.53 ENSG00000126218
HHIP hedgehog interacting protein chr4 0.073 0.26532 7.88577 1.1075 0.169 4.497 −26.58 ENSG00000164161
ARL2-SNX15 - chr11 0.361 0.39062 8.29552 11.168 0.376 9.732 −25.90 -
HES4 hairy and enhancer of split 4 chr1 0.3015 0.46829 16.2396 1.0894 0.385 8.664 −22.51 ENSG00000188290
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial chr2 0.5547 0.36585 17.6005 3.0486 0.460 10.325 −22.43 ENSG00000186281
  1. Genes which were differentially expressed as determined by Cufflinks, after normalization to a panel of housekeeping genes. The fold change is the ratio of RASF FPKM to control FPKM. Genes with a fold change of 1.2-fold or greater were defined as significant. The genes were ranked on their fold change and the 10 with the highest or lowest fold changes are listed here.