RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis

Cell & Bioscience

Table 2 Gene/isoform expression summary

	Genes
	Control	RA Patients
Total Genes Expressed	12,977	13,445
Control Only	214
RA Patients Only		682
Up-regulated (2-fold or greater difference)		122
Down-regulated (2-fold or greater difference)		155
	Known Isoforms
	Control	RA Patients
Total Known Isoforms Expressed	20,647	21,102
Control Only	526
RA Patients Only		981
Up-regulated (2-fold or greater difference)		343
Down-regulated (2-fold or greater difference)		262
	Novel Isoforms
	Control	RA Patients
Total Novel Isoforms Expressed	42,124	42,171
Control Only	105
RA Patients Only		152
Up-regulated (2-fold or greater difference)		561
Down-regulated (2-fold or greater difference)		520

Genes, known isoforms and novel isoforms expressed in control synovial fibroblasts and synovial fibroblasts from patients with rheumatoid arthritis. Expression determined by Cufflinks, after normalization to a panel of housekeeping genes. The fold change is the ratio of RA FPKM to WT FPKM.

ISSN: 2045-3701